Synthesis and biodistribution of 111In, 67Ga and 153Gd-radiolabelled conjugates of nitroimidazoles with bifunctional complexing agents: Imaging agents for hypoxic tissue?

Timothy J. Norman; Fiona C. Smith; David Parker; Alice Harrison; Louise Royle; Carole A. Walker

doi:10.1080/10610279508028940

Synthesis and biodistribution of ¹¹¹In, ⁶⁷Ga and ¹⁵³Gd-radiolabelled conjugates of nitroimidazoles with bifunctional complexing agents: Imaging agents for hypoxic tissue?

Timothy J. Norman
, Fiona C. Smith
, David Parker^*
, Alice Harrison
, Louise Royle
, Carole A. Walker

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

13 Citations (Scopus)

Abstract

Conjugates of the putative hypoxia-selective agent 2-nitroimida-zole with bifunctional complexing agents have been prepared and radiolabelled with ¹¹¹In, ⁶⁷Ga or ¹⁵³Gd. Although some evidence for tumour localisation was found control experiments revealed that the gallium and indium labelled complexes of the simple ligand 1,4,7-triazacyclononane-triacetate are themselves promising tumour-imaging agents.

Original language	English
Pages (from-to)	305-308
Number of pages	4
Journal	Supramolecular Chemistry
Volume	4
Issue number	4
DOIs	https://doi.org/10.1080/10610279508028940
Publication status	Published - 1 Apr 1995

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10.1080/10610279508028940

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title = "Synthesis and biodistribution of 111In, 67Ga and 153Gd-radiolabelled conjugates of nitroimidazoles with bifunctional complexing agents: Imaging agents for hypoxic tissue?",

abstract = "Conjugates of the putative hypoxia-selective agent 2-nitroimida-zole with bifunctional complexing agents have been prepared and radiolabelled with 111In, 67Ga or 153Gd. Although some evidence for tumour localisation was found control experiments revealed that the gallium and indium labelled complexes of the simple ligand 1,4,7-triazacyclononane-triacetate are themselves promising tumour-imaging agents.",

author = "Norman, \{Timothy J.\} and Smith, \{Fiona C.\} and David Parker and Alice Harrison and Louise Royle and Walker, \{Carole A.\}",

year = "1995",

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language = "English",

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Synthesis and biodistribution of ¹¹¹In, ⁶⁷Ga and ¹⁵³Gd-radiolabelled conjugates of nitroimidazoles with bifunctional complexing agents: Imaging agents for hypoxic tissue? / Norman, Timothy J.; Smith, Fiona C.; Parker, David et al.
In: Supramolecular Chemistry, Vol. 4, No. 4, 01.04.1995, p. 305-308.

Research output: Contribution to journal › Journal article › peer-review

TY - JOUR

T1 - Synthesis and biodistribution of 111In, 67Ga and 153Gd-radiolabelled conjugates of nitroimidazoles with bifunctional complexing agents

T2 - Imaging agents for hypoxic tissue?

AU - Norman, Timothy J.

AU - Smith, Fiona C.

AU - Parker, David

AU - Harrison, Alice

AU - Royle, Louise

AU - Walker, Carole A.

PY - 1995/4/1

Y1 - 1995/4/1

N2 - Conjugates of the putative hypoxia-selective agent 2-nitroimida-zole with bifunctional complexing agents have been prepared and radiolabelled with 111In, 67Ga or 153Gd. Although some evidence for tumour localisation was found control experiments revealed that the gallium and indium labelled complexes of the simple ligand 1,4,7-triazacyclononane-triacetate are themselves promising tumour-imaging agents.

AB - Conjugates of the putative hypoxia-selective agent 2-nitroimida-zole with bifunctional complexing agents have been prepared and radiolabelled with 111In, 67Ga or 153Gd. Although some evidence for tumour localisation was found control experiments revealed that the gallium and indium labelled complexes of the simple ligand 1,4,7-triazacyclononane-triacetate are themselves promising tumour-imaging agents.

UR - https://www.scopus.com/pages/publications/84973069314

U2 - 10.1080/10610279508028940

DO - 10.1080/10610279508028940

M3 - Journal article

AN - SCOPUS:84973069314

SN - 1061-0278

VL - 4

SP - 305

EP - 308

JO - Supramolecular Chemistry

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IS - 4

ER -

Synthesis and biodistribution of ¹¹¹In, ⁶⁷Ga and ¹⁵³Gd-radiolabelled conjugates of nitroimidazoles with bifunctional complexing agents: Imaging agents for hypoxic tissue?

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