Syntheses of Diverse Natural Products via Dual-mode Lewis Acid Induced Cascade Cyclization Reactions

  • Guangyan Du
  • , Gaopeng Wang
  • , Wenjing Ma
  • , Qianqian Yang
  • , Wenli Bao
  • , Xuefeng Liang
  • , Lizhi Zhu
  • , Chi Sing Lee*
  • *Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

23 Citations (Scopus)

Abstract

The σ/π-binding properties of a series of Lewis acids was studied using DFT calculations. The results led to the identification of Zn(II)/In(III) as a suitable dual-mode Lewis acid for use in promoting cascade cyclization reactions. Based on this finding, we developed three new types of dual-mode Lewis acid induced cascade cyclization reactions and have demonstrated the utilities of each process in natural product synthesis.

Original languageEnglish
Pages (from-to)1394-1406
JournalSynlett
Volume28
Issue number12
Early online date6 Apr 2017
DOIs
Publication statusPublished - Jul 2017

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