Abstract
Bisjaponins A (1) and B (2), two new dimeric ent-kaurane diterpenoids connected with a rare four-membered carbon ring, which was formed by [2+2] reaction, were isolated from the aerial parts of Isodon japonicus. Their structures were elucidated by the analysis of spectroscopic evidence including extensive 2D NMR and MS data. Both the compounds were inactive for their cytotoxicity against human tumor cell lines, K562 and HepG2.
Original language | English |
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Pages (from-to) | 3574-3577 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 49 |
Issue number | 22 |
DOIs | |
Publication status | Published - 26 May 2008 |
Scopus Subject Areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
User-Defined Keywords
- [2+2] cycloaddition
- Dimer
- ent-Kaurane
- Four-membered carbon ring
- Isodon japonicus