Symmetric and asymmetric ent-kaurane dimers isolated from Isodon japonicus

Li Bin Yang, Jing Yang, Li Mei Li, Chun Lei, Yong Zhao, Sheng Xiong Huang, Wei Lie Xiao, Quan Bin Han, Jian Xin Pu*, Han Dong Sun*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

14 Citations (Scopus)


Bisjaponins A (1) and B (2), two new dimeric ent-kaurane diterpenoids connected with a rare four-membered carbon ring, which was formed by [2+2] reaction, were isolated from the aerial parts of Isodon japonicus. Their structures were elucidated by the analysis of spectroscopic evidence including extensive 2D NMR and MS data. Both the compounds were inactive for their cytotoxicity against human tumor cell lines, K562 and HepG2.

Original languageEnglish
Pages (from-to)3574-3577
Number of pages4
JournalTetrahedron Letters
Issue number22
Publication statusPublished - 26 May 2008

Scopus Subject Areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

User-Defined Keywords

  • [2+2] cycloaddition
  • Dimer
  • ent-Kaurane
  • Four-membered carbon ring
  • Isodon japonicus


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