Suppressive effects of QFGJS, a preparation from an anti-arthritic herbal formula, on rat experimental adjuvant-induced arthritis

Xiong Cai, Hua Zhou, Fan Wong Yuen, Ying Xie, Qiu Liu Zhong, Zhi Hong Jiang, Zhaoxiang BIAN, Xi Xu Hong, Liang LIU*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

To analyze the anti-arthritic effects of QFGJS (a pharmaceutical preparation from herbs) on rheumatoid arthritis, adjuvant-induced arthritis (AIA) was established in male SD rats, and two administration protocols, i.e., oral treatment with different doses of QFGJS on the day of arthritis induction or on the day when visible clinical signs of arthritis occurred, were initiated and continued until day 30. Treatments with QFGJS using both administration protocols significantly suppressed the incidence and severity of arthritis in a dose-dependent manner, showing dramatic reduction of paw swelling and ESR throughout the disease progression of AIA. Radiological and histopathological examinations showed markedly decreased tissue and bone destruction of ankle joints in the QFGJS-treated rats. The serum levels of TNF-α, IL-1β, and IL-6 were significantly decreased in the QFGJS-treated rats. QFGJS demonstrates pronounced anti-arthritic effects on AIA, indicating that this herbal preparation would be a potent candidate as a novel botanical drug for further investigation.

Original languageEnglish
Pages (from-to)586-594
Number of pages9
JournalBiochemical and Biophysical Research Communications
Volume337
Issue number2
DOIs
Publication statusPublished - 18 Nov 2005

Scopus Subject Areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

User-Defined Keywords

  • Adjuvant-induced arthritis
  • Anti-arthritis
  • Herbal medicine
  • Pro-inflammatory cytokines
  • QFGJS
  • Rheumatoid arthritis

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