TY - JOUR
T1 - Suppression of spectral interference in dual-elemental analysis of single particles using triple quadrupole ICP-MS
AU - Chun, Ka Him
AU - Lum, Judy Tsz Shan
AU - Leung, Kelvin Sze Yin
N1 - Funding Information:
Kelvin Sze-Yin Leung thanks the funding support from the Innovation and Technology Commission (PRP/048/19FX). The authors thank the Hong Kong Research Grants Council (HKBU 12302020 and 12302821) for their financial support.
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/9/15
Y1 - 2022/9/15
N2 - Single particle-inductively coupled plasma-mass spectrometry (SP-ICP-MS) was used in the analysis of single particles/cells. Although quadrupole mass analyzers are widely used, the long settling time restricts measurement to single elements in individual particles. Recently, dual-elemental analysis has successfully been developed with the assistance of oxygen gas in the collision cell. This simple approach greatly expands the capability of quadrupole-based ICP-MS.In this study, we adopted bandpass mode in the first quadrupole (Q1) to improve the limit of detection of single particles against spectral interference. A model was developed to explain the rationale behind the selection of quadrupole voltages. The quadrupole voltages were optimized systematically so that the mass bandwidth of Q1 allowed the transmission of two target analytes while the interference species were rejected. As a result, the signal from the polyatomic interference was reduced by 98% with no significant change in the analyte signal.The bandpass mode was further applied to accurately determine the isotope ratio of 109Ag/107Ag in 80-nm Ag nanoparticles, as well as the Ag content in AgSn alloy particles, under the polyatomic interference of 91Zr16O originating from dissolved ions and particles. This technique was further applied to the determination of two Yb isotopes in algal cells with interference from Gd. Results indicate that this approach has great potential for assessing single particles and biological cells in the presence of severe interference from imaging agents, drugs, or biological fluids.
AB - Single particle-inductively coupled plasma-mass spectrometry (SP-ICP-MS) was used in the analysis of single particles/cells. Although quadrupole mass analyzers are widely used, the long settling time restricts measurement to single elements in individual particles. Recently, dual-elemental analysis has successfully been developed with the assistance of oxygen gas in the collision cell. This simple approach greatly expands the capability of quadrupole-based ICP-MS.In this study, we adopted bandpass mode in the first quadrupole (Q1) to improve the limit of detection of single particles against spectral interference. A model was developed to explain the rationale behind the selection of quadrupole voltages. The quadrupole voltages were optimized systematically so that the mass bandwidth of Q1 allowed the transmission of two target analytes while the interference species were rejected. As a result, the signal from the polyatomic interference was reduced by 98% with no significant change in the analyte signal.The bandpass mode was further applied to accurately determine the isotope ratio of 109Ag/107Ag in 80-nm Ag nanoparticles, as well as the Ag content in AgSn alloy particles, under the polyatomic interference of 91Zr16O originating from dissolved ions and particles. This technique was further applied to the determination of two Yb isotopes in algal cells with interference from Gd. Results indicate that this approach has great potential for assessing single particles and biological cells in the presence of severe interference from imaging agents, drugs, or biological fluids.
KW - Bandpass mode
KW - Dual-mass
KW - Nanoparticles
KW - Single particle ICP-MS
KW - Spectral interference
UR - http://www.scopus.com/inward/record.url?scp=85136316217&partnerID=8YFLogxK
U2 - 10.1016/j.aca.2022.340258
DO - 10.1016/j.aca.2022.340258
M3 - Journal article
C2 - 36068058
AN - SCOPUS:85136316217
SN - 0003-2670
VL - 1226
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
M1 - 340258
ER -