Suppression of matrix ions by N-phosphorylation labeling using matrix-assisted laser desorption–ionization time-of-flight mass spectrometry

Xiang Gao; Zhi Tang; Minghua Lu; Hongxia Liu; Yuyang Jiang; Yufen Zhao; Zongwei CAI

doi:10.1039/c2cc36091h

Suppression of matrix ions by N-phosphorylation labeling using matrix-assisted laser desorption–ionization time-of-flight mass spectrometry

Xiang Gao
, Zhi Tang
, Minghua Lu
, Hongxia Liu
, Yuyang Jiang
, Yufen Zhao
, Zongwei CAI^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

38 Citations (Scopus)

Abstract

N-Phosphorylation labeling was utilized to analyze small metabolites using matrix-assisted laser desorption–ionization time-of-flight mass spectrometry (MALDI-TOF MS). The incorporation of a neutral phosphoryl group with high gas-phase proton affinity not only improved the ionization efficiency of the target molecules, but also greatly reduced the matrix background interference.

Original language	English
Pages (from-to)	10198-10200
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	82
DOIs	https://doi.org/10.1039/c2cc36091h
Publication status	Published - 19 Sept 2012

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title = "Suppression of matrix ions by N-phosphorylation labeling using matrix-assisted laser desorption–ionization time-of-flight mass spectrometry",

abstract = "N-Phosphorylation labeling was utilized to analyze small metabolites using matrix-assisted laser desorption–ionization time-of-flight mass spectrometry (MALDI-TOF MS). The incorporation of a neutral phosphoryl group with high gas-phase proton affinity not only improved the ionization efficiency of the target molecules, but also greatly reduced the matrix background interference.",

author = "Xiang Gao and Zhi Tang and Minghua Lu and Hongxia Liu and Yuyang Jiang and Yufen Zhao and Zongwei CAI",

note = "This work was financially supported by the National Science Foundation of China (No. 21172129 and 20928005) and the Ministry of Science and Technology of China (2011DFA30620).",

year = "2012",

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doi = "10.1039/c2cc36091h",

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T1 - Suppression of matrix ions by N-phosphorylation labeling using matrix-assisted laser desorption–ionization time-of-flight mass spectrometry

AU - Gao, Xiang

AU - Tang, Zhi

AU - Lu, Minghua

AU - Liu, Hongxia

AU - Jiang, Yuyang

AU - Zhao, Yufen

AU - CAI, Zongwei

N1 - This work was financially supported by the National Science Foundation of China (No. 21172129 and 20928005) and the Ministry of Science and Technology of China (2011DFA30620).

PY - 2012/9/19

Y1 - 2012/9/19

N2 - N-Phosphorylation labeling was utilized to analyze small metabolites using matrix-assisted laser desorption–ionization time-of-flight mass spectrometry (MALDI-TOF MS). The incorporation of a neutral phosphoryl group with high gas-phase proton affinity not only improved the ionization efficiency of the target molecules, but also greatly reduced the matrix background interference.

AB - N-Phosphorylation labeling was utilized to analyze small metabolites using matrix-assisted laser desorption–ionization time-of-flight mass spectrometry (MALDI-TOF MS). The incorporation of a neutral phosphoryl group with high gas-phase proton affinity not only improved the ionization efficiency of the target molecules, but also greatly reduced the matrix background interference.

UR - https://www.scopus.com/pages/publications/84866688211

U2 - 10.1039/c2cc36091h

DO - 10.1039/c2cc36091h

M3 - Journal article

C2 - 22962666

AN - SCOPUS:84866688211

SN - 1359-7345

VL - 48

SP - 10198

EP - 10200

JO - Chemical Communications

JF - Chemical Communications

IS - 82

ER -

Suppression of matrix ions by N-phosphorylation labeling using matrix-assisted laser desorption–ionization time-of-flight mass spectrometry

Abstract

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