Suppression of matrix ions by N-phosphorylation labeling using matrix-assisted laser desorption–ionization time-of-flight mass spectrometry

Xiang Gao, Zhi Tang, Minghua Lu, Hongxia Liu, Yuyang Jiang, Yufen Zhao, Zongwei CAI*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

N-Phosphorylation labeling was utilized to analyze small metabolites using matrix-assisted laser desorption–ionization time-of-flight mass spectrometry (MALDI-TOF MS). The incorporation of a neutral phosphoryl group with high gas-phase proton affinity not only improved the ionization efficiency of the target molecules, but also greatly reduced the matrix background interference.

Original languageEnglish
Pages (from-to)10198-10200
Number of pages3
JournalChemical Communications
Volume48
Issue number82
DOIs
Publication statusPublished - 19 Sep 2012

Scopus Subject Areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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