TY - JOUR
T1 - Supplementation of Micronutrient Selenium in Metabolic Diseases
T2 - Its Role as an Antioxidant
AU - Wang, Ning
AU - Tan, Hor Yue
AU - Li, Sha
AU - Xu, Yu
AU - Guo, Wei
AU - Feng, Yibin
N1 - Funding Information:
The study was partially financially supported by grants from the research council of the University of Hong Kong (Project Codes: 104003422, 104003919, 104004092, 104004460, and 104004462), the Research Grants Committee (RGC) of Hong Kong, HKSAR (Project Codes: 766211 and 17152116), Gala Family Trust (Project Code: 200007008), Shenzhen Science and Technology Innovation Commission (Project Code: JCYJ20140903112959964), Government Matching Grant Scheme (Project Code: 207060411), and Contract research (Project Codes: 260007482 and 260007830).
Publisher Copyright:
© 2017 Ning Wang et al.
PY - 2017/12/26
Y1 - 2017/12/26
N2 - Selenium is an essential mineral naturally found in soil, water, and some of the food. As an antioxidant, it is one of the necessary trace elements in human body and has been suggested as a dietary supplement for health benefit. Although the human body only needs a trace amount of selenium every day, plenty of recent studies have revealed that selenium is indispensable for maintaining normal functions of metabolism. In this study, we reviewed the antioxidant role of nutritional supplementation of selenium in the management of major chronic metabolic disorders, including hyperlipidaemia, hyperglycaemia, and hyperphenylalaninemia. Clinical significance of selenium deficiency in chronic metabolic diseases was elaborated, while clinical and experimental observations of dietary supplementation of selenium in treating chronic metabolic diseases, such as diabetes, arteriosclerosis, and phenylketonuria, were summarized. Toxicity and recommended dose of selenium were discussed. The mechanism of action was also proposed via inspecting the interaction of molecular networks and predicting target protein such as xanthine dehydrogenase in various diseases. Future direction in studying the role of selenium in metabolic disorders was also highlighted. In conclusion, highlighting the beneficial role of selenium in this review would advance our knowledge of the dietary management of chronic metabolic diseases.
AB - Selenium is an essential mineral naturally found in soil, water, and some of the food. As an antioxidant, it is one of the necessary trace elements in human body and has been suggested as a dietary supplement for health benefit. Although the human body only needs a trace amount of selenium every day, plenty of recent studies have revealed that selenium is indispensable for maintaining normal functions of metabolism. In this study, we reviewed the antioxidant role of nutritional supplementation of selenium in the management of major chronic metabolic disorders, including hyperlipidaemia, hyperglycaemia, and hyperphenylalaninemia. Clinical significance of selenium deficiency in chronic metabolic diseases was elaborated, while clinical and experimental observations of dietary supplementation of selenium in treating chronic metabolic diseases, such as diabetes, arteriosclerosis, and phenylketonuria, were summarized. Toxicity and recommended dose of selenium were discussed. The mechanism of action was also proposed via inspecting the interaction of molecular networks and predicting target protein such as xanthine dehydrogenase in various diseases. Future direction in studying the role of selenium in metabolic disorders was also highlighted. In conclusion, highlighting the beneficial role of selenium in this review would advance our knowledge of the dietary management of chronic metabolic diseases.
UR - http://www.scopus.com/inward/record.url?scp=85042603223&partnerID=8YFLogxK
U2 - 10.1155/2017/7478523
DO - 10.1155/2017/7478523
M3 - Review article
C2 - 29441149
AN - SCOPUS:85042603223
SN - 1942-0900
VL - 2017
JO - Oxidative Medicine and Cellular Longevity
JF - Oxidative Medicine and Cellular Longevity
M1 - 7478523
ER -