Sulfide‐Catalyzed Trifluoromethylthiolation‐Cyclization of Tryptamine Derivatives

Rui Guo, Baohua Cai, Ming Yu Jin, Huaixue Mu, Jun (Joelle) Wang

Research output: Contribution to journalArticlepeer-review

Abstract

Trippy triptamines: An SCF3 group can be incorporated in tryptamine derivatives via a sulfide-catalyzed cascade trifluoromethylthiolation-cyclization. A series of C(3)-CF3S pyrrolidinoindolines were obtained in moderate to good yields under mild conditions. Furthermore, some enantioselectivity was observed when using chiral sulfide thiocineole as a catalyst.
A catalytic method for the incorporation of an SCF3 group to tryptamine derivatives was developed via a sulfide-catalyzed cascade trifluoromethylthiolation-cyclization. A series of C(3)-CF3S pyrrolidinoindolines were obtained in moderate to good yields under mild conditions. Furthermore, some enantioselectivity was observed when using chiral sulfide thiocineole as a catalyst.
Original languageEnglish
Pages (from-to)687-690
Number of pages4
JournalAsian Journal of Organic Chemistry
Volume8
Issue number5
DOIs
Publication statusPublished - May 2019

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