Study on interaction of L-tryptophan with p-sulfonatocalix[4]arene by spectrofluorometry

Wen Ye Li, Ying Li Wei, Wen Ting An, Shao Min Shuang*, Man Shing Wong*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review


The interactions between L-tryptophan(L-Trp) and water-soluble p-sulfonatocalix[4]-arene (SCX4) were investigated by spectrofluorometry. The effect of pH was discussed. The interaction process was estimated from the thermodynamic viewpoint. The SCX4 was found to be able to adjust its conformation to fit the size of L-Trp, and the benzene of L-Trp penetrated into the hydrophobic cavity of SCX4. Meanwhile, the binding mechanism was further elucidated by 1HNMR and molecular mechanics calculations.

Original languageEnglish
Pages (from-to)1592-1594
Number of pages3
JournalChinese Chemical Letters
Issue number12
Publication statusPublished - Dec 2006

Scopus Subject Areas

  • Chemistry(all)

User-Defined Keywords

  • L-Tryptophan
  • p-sulfonatocalix[4]arene
  • fluorescence


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