TY - JOUR
T1 - Study of the Repellent Activity of 60 Essential Oils and Their Main Constituents against Aedes albopictus, and Nano-Formulation Development
AU - Wu, Weifeng
AU - Yang, Yu
AU - Feng, Yingmiao
AU - Ren, Xiaofei
AU - Li, Yuling
AU - Li, Wenjiao
AU - Huang, Jietong
AU - Kong, Lingjia
AU - Chen, Xiaole
AU - Lin, Zhongze
AU - Hou, Xiaohui
AU - Zhang, Longlai
AU - Chen, Yajie
AU - Sheng, Zhaojun
AU - Hong, Weiqian
N1 - Funding Information:
The authors gratefully acknowledge Wuyi University-Hong Kong and Macao Joint Research Fund (No. 2021WGALH10, Wuyi University), the Start-up Foundation for High-level Talents of Wuyi University (No. 2017RC04, Wuyi University), Special Fund Project of Science and Technology Innovation Strategy in Guangdong Province (No. Jiangke(2018)352, Department of Science and Technology of Guangdong Province), Jiangmen Science and Technology Project of Basic and Theoretical Science Research (No. 2021030101400004873, Jiangmen Science and Technology Bureau), and the Project of Innovative and Entrepreneurship for College Students in Wuyi University (No. 202111349298, Wuyi University) for the financial support.
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/12
Y1 - 2022/12
N2 - Mosquitoes are one of the most important disease vectors from a medical viewpoint in that they transmit several diseases such as malaria, filariasis, yellow and Dengue fever. Mosquito vector control and personal protection from mosquito bites are currently the most efficient ways to prevent these diseases. Several synthetic repellents such as DEET, ethyl butylacetylaminopropionate (IR3535) and 1-(1-methylpropoxycarbonyl)-2-(2-hydroxyethyl)piperidine) (Picaridin), have been widely used to prevent humans from receiving mosquito bites. However, the use of synthetic repellents has raised several environment and health concerns. Therefore, essential oils (EOs) as natural alternatives receive our attention. In order to discover highly effective mosquito repellents from natural sources, the repellent activity of 60 commercial EOs against Ae. albopictus was screened in this study. Eight EOs including cinnamon, marjoram, lemongrass, bay, chamomile, jasmine, peppermint2, and thyme, showed a suitable repellent rate (>40%) at the tested dose of 10 μg/cm2. Then, their main constituents were analyzed by GC-MS, and the active constituents were identified. The most active compounds including cinnamaldehyde, citral and terpinen-4-ol, exhibited an 82%, 65% and 60% repellent rate, respectively. Moreover, the nanoemulsions of the three active compounds were prepared and characterized. In the arm-in-cage assay, the protection times of the nanoemulsions of cinnamaldehyde and citral were significantly extended compared with their normal solutions. This study provides several lead compounds to develop new mosquito repellents, and it suggests that nanoemulsification is an effective method for improving the duration of the activity of natural repellents.
AB - Mosquitoes are one of the most important disease vectors from a medical viewpoint in that they transmit several diseases such as malaria, filariasis, yellow and Dengue fever. Mosquito vector control and personal protection from mosquito bites are currently the most efficient ways to prevent these diseases. Several synthetic repellents such as DEET, ethyl butylacetylaminopropionate (IR3535) and 1-(1-methylpropoxycarbonyl)-2-(2-hydroxyethyl)piperidine) (Picaridin), have been widely used to prevent humans from receiving mosquito bites. However, the use of synthetic repellents has raised several environment and health concerns. Therefore, essential oils (EOs) as natural alternatives receive our attention. In order to discover highly effective mosquito repellents from natural sources, the repellent activity of 60 commercial EOs against Ae. albopictus was screened in this study. Eight EOs including cinnamon, marjoram, lemongrass, bay, chamomile, jasmine, peppermint2, and thyme, showed a suitable repellent rate (>40%) at the tested dose of 10 μg/cm2. Then, their main constituents were analyzed by GC-MS, and the active constituents were identified. The most active compounds including cinnamaldehyde, citral and terpinen-4-ol, exhibited an 82%, 65% and 60% repellent rate, respectively. Moreover, the nanoemulsions of the three active compounds were prepared and characterized. In the arm-in-cage assay, the protection times of the nanoemulsions of cinnamaldehyde and citral were significantly extended compared with their normal solutions. This study provides several lead compounds to develop new mosquito repellents, and it suggests that nanoemulsification is an effective method for improving the duration of the activity of natural repellents.
KW - Aedes albopictus
KW - essential oil
KW - nanoemulsion
KW - repellent
UR - http://www.scopus.com/inward/record.url?scp=85144670432&partnerID=8YFLogxK
U2 - 10.3390/insects13121077
DO - 10.3390/insects13121077
M3 - Journal article
AN - SCOPUS:85144670432
SN - 2075-4450
VL - 13
JO - Insects
JF - Insects
IS - 12
M1 - 1077
ER -
