Studies on the aconitine-type alkaloids in the roots of Aconitum Carmichaeli Debx. by HPLC/ESIMS/MSn

Hao Yue, Zifeng Pi, Fengrui Song, Zhiqiang Liu, Zongwei CAI, Shuying Liu*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

118 Citations (Scopus)


Studies of aconitine-type alkaloids in the Chinese herb Aconitum Carmichaeli were performed by HPLC/ESIMS/MSn and FTICR/ESIMS in positive ion mode. The characteristic fragmentation pathways in the MSn spectra were summarized based on previously published research literature and further study. According to the fragmentation pathways of mass spectrometry, results from the analysis of standard compounds and reports from literature, 111 compounds were identified or deduced in a total of 117 found compounds in A. Carmichaeli. In the 11 monoester-diterpenoid alkaloids (MDA), 10 diesterditerpenoid alkaloids (DDA) and 81 lipo-alkaloids, the novel alkaloids including 1 MDA, 2 DDA and 48 lipo-alkaloids were detected. In addition, 1 DDA, 7 lipo-alkaloids and 2 alkaloids with small molecular weights that possess C19-norditerpenoid skeleton were reported in A. Carmichaeli for the first time.

Original languageEnglish
Pages (from-to)1800-1807
Number of pages8
Issue number5
Publication statusPublished - 15 Mar 2009

Scopus Subject Areas

  • Analytical Chemistry

User-Defined Keywords

  • Aconitine-type alkaloids
  • Aconitum Carmichaeli
  • C-norditerpenoid


Dive into the research topics of 'Studies on the aconitine-type alkaloids in the roots of Aconitum Carmichaeli Debx. by HPLC/ESIMS/MSn'. Together they form a unique fingerprint.

Cite this