Structure identification of euphorbia factor L3 and its induction of apoptosis through the mitochondrial pathway

Jian Ye Zhang; Yong Ju Liang; Hubiao CHEN; Li Sheng Zheng; Yan Jun Mi; Fang Wang; Xiao Qin Zhao; Xiao Kun Wang; Hui Zhang; Li Wu Fu

doi:10.3390/molecules16043222

Structure identification of euphorbia factor L3 and its induction of apoptosis through the mitochondrial pathway

Jian Ye Zhang
, Yong Ju Liang
, Hubiao CHEN
, Li Sheng Zheng
, Yan Jun Mi
, Fang Wang
, Xiao Qin Zhao
, Xiao Kun Wang
, Hui Zhang
, Li Wu Fu^*

^*Corresponding author for this work

School of Chinese Medicine

Research output: Contribution to journal › Journal article › peer-review

24 Citations (Scopus)

Abstract

In this article, we have focused on the structure identification of Euphorbia factor L3 belonging to the lathyrane diterpenoids isolated from Caper Euphorbia Seed. Its anticancer activity in vitro against lung cancer A549 cells was also investigated and the IC50 values were 34.04 ± 3.99 μM. Furthermore, Euphorbia factor L3 could induce apoptosis in A549 cells via the mitochondrial pathway including loss of mitochondrial potential and release of cytochrome c.

Original language	English
Pages (from-to)	3222-3231
Number of pages	10
Journal	Molecules
Volume	16
Issue number	4
DOIs	https://doi.org/10.3390/molecules16043222
Publication status	Published - Apr 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

User-Defined Keywords

Apoptosis
Caper euphorbia seed
Euphorbia factor L3
Mitochondrial pathway

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10.3390/molecules16043222

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title = "Structure identification of euphorbia factor L3 and its induction of apoptosis through the mitochondrial pathway",

abstract = "In this article, we have focused on the structure identification of Euphorbia factor L3 belonging to the lathyrane diterpenoids isolated from Caper Euphorbia Seed. Its anticancer activity in vitro against lung cancer A549 cells was also investigated and the IC50 values were 34.04 ± 3.99 μM. Furthermore, Euphorbia factor L3 could induce apoptosis in A549 cells via the mitochondrial pathway including loss of mitochondrial potential and release of cytochrome c.",

keywords = "Apoptosis, Caper euphorbia seed, Euphorbia factor L3, Mitochondrial pathway",

author = "Zhang, \{Jian Ye\} and Liang, \{Yong Ju\} and Hubiao CHEN and Zheng, \{Li Sheng\} and Mi, \{Yan Jun\} and Fang Wang and Zhao, \{Xiao Qin\} and Wang, \{Xiao Kun\} and Hui Zhang and Fu, \{Li Wu\}",

note = "The work was supported by grants from Natural science foundation of Guangdong province (No. 2008B030301331), Research Project of Guangzhou Education Bureau (10A167), Traditional Chinese Medicine of Guangdong Province (2010420), Doctor Initial Funding of Guangzhou Medical College (2008C16) and Open Project Program (2009) of State Key Laboratory of Oncology in South China.",

year = "2011",

month = apr,

doi = "10.3390/molecules16043222",

language = "English",

volume = "16",

pages = "3222--3231",

journal = "Molecules",

issn = "1420-3049",

publisher = "MDPI",

number = "4",

}

TY - JOUR

T1 - Structure identification of euphorbia factor L3 and its induction of apoptosis through the mitochondrial pathway

AU - Zhang, Jian Ye

AU - Liang, Yong Ju

AU - CHEN, Hubiao

AU - Zheng, Li Sheng

AU - Mi, Yan Jun

AU - Wang, Fang

AU - Zhao, Xiao Qin

AU - Wang, Xiao Kun

AU - Zhang, Hui

AU - Fu, Li Wu

N1 - The work was supported by grants from Natural science foundation of Guangdong province (No. 2008B030301331), Research Project of Guangzhou Education Bureau (10A167), Traditional Chinese Medicine of Guangdong Province (2010420), Doctor Initial Funding of Guangzhou Medical College (2008C16) and Open Project Program (2009) of State Key Laboratory of Oncology in South China.

PY - 2011/4

Y1 - 2011/4

N2 - In this article, we have focused on the structure identification of Euphorbia factor L3 belonging to the lathyrane diterpenoids isolated from Caper Euphorbia Seed. Its anticancer activity in vitro against lung cancer A549 cells was also investigated and the IC50 values were 34.04 ± 3.99 μM. Furthermore, Euphorbia factor L3 could induce apoptosis in A549 cells via the mitochondrial pathway including loss of mitochondrial potential and release of cytochrome c.

AB - In this article, we have focused on the structure identification of Euphorbia factor L3 belonging to the lathyrane diterpenoids isolated from Caper Euphorbia Seed. Its anticancer activity in vitro against lung cancer A549 cells was also investigated and the IC50 values were 34.04 ± 3.99 μM. Furthermore, Euphorbia factor L3 could induce apoptosis in A549 cells via the mitochondrial pathway including loss of mitochondrial potential and release of cytochrome c.

KW - Apoptosis

KW - Caper euphorbia seed

KW - Euphorbia factor L3

KW - Mitochondrial pathway

UR - https://www.scopus.com/pages/publications/79955546436

U2 - 10.3390/molecules16043222

DO - 10.3390/molecules16043222

M3 - Journal article

C2 - 21499222

AN - SCOPUS:79955546436

SN - 1420-3049

VL - 16

SP - 3222

EP - 3231

JO - Molecules

JF - Molecules

IS - 4

ER -

Structure identification of euphorbia factor L3 and its induction of apoptosis through the mitochondrial pathway

Abstract

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