Structure identification of euphorbia factor L3 and its induction of apoptosis through the mitochondrial pathway

Jian Ye Zhang, Yong Ju Liang, Hubiao CHEN, Li Sheng Zheng, Yan Jun Mi, Fang Wang, Xiao Qin Zhao, Xiao Kun Wang, Hui Zhang, Li Wu Fu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

In this article, we have focused on the structure identification of Euphorbia factor L3 belonging to the lathyrane diterpenoids isolated from Caper Euphorbia Seed. Its anticancer activity in vitro against lung cancer A549 cells was also investigated and the IC50 values were 34.04 ± 3.99 μM. Furthermore, Euphorbia factor L3 could induce apoptosis in A549 cells via the mitochondrial pathway including loss of mitochondrial potential and release of cytochrome c.

Original languageEnglish
Pages (from-to)3222-3231
Number of pages10
JournalMolecules
Volume16
Issue number4
DOIs
Publication statusPublished - Apr 2011

Scopus Subject Areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

User-Defined Keywords

  • Apoptosis
  • Caper euphorbia seed
  • Euphorbia factor L3
  • Mitochondrial pathway

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