Structure elucidation of two new diterpenoids from Isodon phyllostachys: Phyllostacins A and B

Xian Li, Wei Lie Xiao, Sheng Xiong Huang, Zhi Ying Weng, Yun Heng Shen, Quan Bin Han, Han Dong Sun*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

7 Citations (Scopus)

Abstract

Two new ent-kaurane-derived diterpene derivatives, phyllostacins A (1) and B (2), were isolated from the aerial parts of Isodon phyllostachys, together with two known compounds, irroratin A (3) and serrin B (4). Both 1 and 2 were found to be present as diastereoisomers. In the case of 1, the corresponding diastereoisomeric diacetates 5 and 6 were prepared and separated. The structures of the new compounds were elucidated by extensive 1D- and 2D-NMR spectroscopic methods, in combination with MS experiments. In (D5)pyridine solution, the two epimers of 1 are present in equal amounts, but in CDCl 3 or CD3OD, the (S)-epimer predominates in the mixture of hemiacetals.

Original languageEnglish
Pages (from-to)1181-1186
Number of pages6
JournalHelvetica Chimica Acta
Volume89
Issue number6
DOIs
Publication statusPublished - 27 Jun 2006

Scopus Subject Areas

  • Catalysis
  • Biochemistry
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

User-Defined Keywords

  • Isodon phyllostachys
  • Diterpenoids
  • ent-Kauranoid
  • NMR Spectroscopy
  • Phyllostacin A and B

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