@article{7a10e31423d84ae98d82041b3fce7293,
title = "Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin–MLL interaction",
abstract = "The natural product-like compound 1 was identified as a direct inhibitor of the menin-MLL interaction by in silico screening. Structure-based optimization furnished analogue 1a, which showed significantly higher potency than both the lead structure 1 and the reference compound MI-2.",
author = "Zhong, {Hai Jing} and Lee, {Bo Ra} and Boyle, {Joshua William} and Wanhe Wang and Ma, {Dik Lung} and {Hong Chan}, {Philip Wai} and Leung, {Chung Hang}",
note = "Funding Information: This work is supported by Hong Kong Baptist University (FRG2/14-15/004 and FRG2/15-16/002), the Health and Medical Research Fund (HMRF/14130522), the Research Grants Council (HKBU/201811, HKBU/204612 and HKBU/201913), the French National Research Agency/Research Grants Council Joint Research Scheme (A-HKBU201/12), Inter-institutional Collaborative Research Scheme (RC-ICRS/15-16/02A), National Natural Science Foundation of China (21575121), Guangdong Province Natural Science Foundation (2015A030313816), Hong Kong Baptist University Century Club Sponsorship Scheme 2015, Interdisciplinary Research Matching Scheme (RC-IRMS/14-15/06), the Science and Technology Development Fund, Macao SAR (103/ 2012/A3), the University of Macau (MYRG091(Y3-L2)-ICMS12- LCH, MYRG2015-00137-ICMS-QRCM, MRG023/LCH/2013/ICMS and MRG044/LCH/2015/ICMS) and a Discovery Project Grant (DP160101682) from the Australian Research Council. Publisher copyright: {\textcopyright} The Royal Society of Chemistry 2016",
year = "2016",
month = apr,
day = "30",
doi = "10.1039/c6cc01079b",
language = "English",
volume = "52",
pages = "5788--5791",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "34",
}
