Structure-based discovery of natural-product-like tnf-α inhibitors

Daniel Shiu Hin Chan; Ho Man Lee; Fang Yang; Chi Ming Che; Catherine C.L. Wong; Ruben Abagyan; Chung Hang Leung; Edmond Dik Lung MA

doi:10.1002/anie.200907360

Structure-based discovery of natural-product-like tnf-α inhibitors

Daniel Shiu Hin Chan
, Ho Man Lee
, Fang Yang
, Chi Ming Che
, Catherine C.L. Wong
, Ruben Abagyan
, Chung Hang Leung
, Edmond Dik Lung MA

Department of Chemistry

Research output: Contribution to journal › Review article › peer-review

131 Citations (Scopus)

Abstract

(Figure Presented) Small but effective: Two natural-productlike inhibitors of tumor necrosis factor α (TNF-α represented in green in the picture) have been identified using structure-based virtual screening. These compounds represent only the third and fourth examples of direct targeting of TNF-α by a small molecule. and display potency comparable to that of the strongest TNF-α inhibitor reported to date.

Original language	English
Pages (from-to)	2860-2864
Number of pages	5
Journal	Angewandte Chemie. International Edition
Volume	49
Issue number	16
DOIs	https://doi.org/10.1002/anie.200907360
Publication status	Published - 6 Apr 2010

User-Defined Keywords

Drug discovery
Inhibitors
Natural products
Tumor necrosis factor
Virtual screening

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10.1002/anie.200907360

Cite this

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title = "Structure-based discovery of natural-product-like tnf-α inhibitors",

abstract = "(Figure Presented) Small but effective: Two natural-productlike inhibitors of tumor necrosis factor α (TNF-α represented in green in the picture) have been identified using structure-based virtual screening. These compounds represent only the third and fourth examples of direct targeting of TNF-α by a small molecule. and display potency comparable to that of the strongest TNF-α inhibitor reported to date.",

keywords = "Drug discovery, Inhibitors, Natural products, Tumor necrosis factor, Virtual screening",

author = "Chan, \{Daniel Shiu Hin\} and Lee, \{Ho Man\} and Fang Yang and Che, \{Chi Ming\} and Wong, \{Catherine C.L.\} and Ruben Abagyan and Leung, \{Chung Hang\} and MA, \{Edmond Dik Lung\}",

note = "This work was supported by the Area of Excellence Scheme established under the University Grants Committee of the Hong Kong Special Administrative Region, China (AoE/P-10/01), the University of Hong Kong (University Development Fund), the University of Hong Kong Seed Funding Programme for Applied Research, and the University of Hong Kong Seed Funding Programme for Basic Research.",

year = "2010",

month = apr,

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doi = "10.1002/anie.200907360",

language = "English",

volume = "49",

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T1 - Structure-based discovery of natural-product-like tnf-α inhibitors

AU - Chan, Daniel Shiu Hin

AU - Lee, Ho Man

AU - Yang, Fang

AU - Che, Chi Ming

AU - Wong, Catherine C.L.

AU - Abagyan, Ruben

AU - Leung, Chung Hang

AU - MA, Edmond Dik Lung

N1 - This work was supported by the Area of Excellence Scheme established under the University Grants Committee of the Hong Kong Special Administrative Region, China (AoE/P-10/01), the University of Hong Kong (University Development Fund), the University of Hong Kong Seed Funding Programme for Applied Research, and the University of Hong Kong Seed Funding Programme for Basic Research.

PY - 2010/4/6

Y1 - 2010/4/6

N2 - (Figure Presented) Small but effective: Two natural-productlike inhibitors of tumor necrosis factor α (TNF-α represented in green in the picture) have been identified using structure-based virtual screening. These compounds represent only the third and fourth examples of direct targeting of TNF-α by a small molecule. and display potency comparable to that of the strongest TNF-α inhibitor reported to date.

AB - (Figure Presented) Small but effective: Two natural-productlike inhibitors of tumor necrosis factor α (TNF-α represented in green in the picture) have been identified using structure-based virtual screening. These compounds represent only the third and fourth examples of direct targeting of TNF-α by a small molecule. and display potency comparable to that of the strongest TNF-α inhibitor reported to date.

KW - Drug discovery

KW - Inhibitors

KW - Natural products

KW - Tumor necrosis factor

KW - Virtual screening

UR - https://www.scopus.com/pages/publications/77950498477

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DO - 10.1002/anie.200907360

M3 - Review article

C2 - 20235259

AN - SCOPUS:77950498477

SN - 1433-7851

VL - 49

SP - 2860

EP - 2864

JO - Angewandte Chemie. International Edition

JF - Angewandte Chemie. International Edition

IS - 16

ER -

Structure-based discovery of natural-product-like tnf-α inhibitors

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