@article{a7671cff817044438855513e4f33349a,
title = "Structure-based discovery of natural-product-like tnf-α inhibitors",
abstract = "(Figure Presented) Small but effective: Two natural-productlike inhibitors of tumor necrosis factor α (TNF-α represented in green in the picture) have been identified using structure-based virtual screening. These compounds represent only the third and fourth examples of direct targeting of TNF-α by a small molecule. and display potency comparable to that of the strongest TNF-α inhibitor reported to date.",
keywords = "Drug discovery, Inhibitors, Natural products, Tumor necrosis factor, Virtual screening",
author = "Chan, \{Daniel Shiu Hin\} and Lee, \{Ho Man\} and Fang Yang and Che, \{Chi Ming\} and Wong, \{Catherine C.L.\} and Ruben Abagyan and Leung, \{Chung Hang\} and MA, \{Edmond Dik Lung\}",
note = "This work was supported by the Area of Excellence Scheme established under the University Grants Committee of the Hong Kong Special Administrative Region, China (AoE/P-10/01), the University of Hong Kong (University Development Fund), the University of Hong Kong Seed Funding Programme for Applied Research, and the University of Hong Kong Seed Funding Programme for Basic Research.",
year = "2010",
month = apr,
day = "6",
doi = "10.1002/anie.200907360",
language = "English",
volume = "49",
pages = "2860--2864",
journal = "Angewandte Chemie. International Edition",
issn = "1433-7851",
publisher = "John Wiley \& Sons Ltd",
number = "16",
}