Structure-based discovery of natural-product-like tnf-α inhibitors

Daniel Shiu Hin Chan, Ho Man Lee, Fang Yang, Chi Ming Che, Catherine C.L. Wong, Ruben Abagyan, Chung Hang Leung, Edmond Dik Lung MA

Research output: Contribution to journalReview articlepeer-review

117 Citations (Scopus)


(Figure Presented) Small but effective: Two natural-productlike inhibitors of tumor necrosis factor α (TNF-α represented in green in the picture) have been identified using structure-based virtual screening. These compounds represent only the third and fourth examples of direct targeting of TNF-α by a small molecule. and display potency comparable to that of the strongest TNF-α inhibitor reported to date.

Original languageEnglish
Pages (from-to)2860-2864
Number of pages5
JournalAngewandte Chemie. International Edition
Issue number16
Publication statusPublished - 6 Apr 2010

Scopus Subject Areas

  • Catalysis
  • Chemistry(all)

User-Defined Keywords

  • Drug discovery
  • Inhibitors
  • Natural products
  • Tumor necrosis factor
  • Virtual screening


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