Structure-based discovery of natural-product-like tnf-α inhibitors

Daniel Shiu Hin Chan; Ho Man Lee; Fang Yang; Chi Ming Che; Catherine C.L. Wong; Ruben Abagyan; Chung Hang Leung; Edmond Dik Lung MA

doi:10.1002/anie.200907360

Structure-based discovery of natural-product-like tnf-α inhibitors

Daniel Shiu Hin Chan, Ho Man Lee, Fang Yang, Chi Ming Che, Catherine C.L. Wong, Ruben Abagyan, Chung Hang Leung, Edmond Dik Lung MA

Department of Chemistry

Research output: Contribution to journal › Review article › peer-review

119 Citations (Scopus)

Abstract

(Figure Presented) Small but effective: Two natural-productlike inhibitors of tumor necrosis factor α (TNF-α represented in green in the picture) have been identified using structure-based virtual screening. These compounds represent only the third and fourth examples of direct targeting of TNF-α by a small molecule. and display potency comparable to that of the strongest TNF-α inhibitor reported to date.

Original language	English
Pages (from-to)	2860-2864
Number of pages	5
Journal	Angewandte Chemie. International Edition
Volume	49
Issue number	16
DOIs	https://doi.org/10.1002/anie.200907360
Publication status	Published - 6 Apr 2010

Scopus Subject Areas

Catalysis
Chemistry(all)

User-Defined Keywords

Drug discovery
Inhibitors
Natural products
Tumor necrosis factor
Virtual screening

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10.1002/anie.200907360

Cite this

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title = "Structure-based discovery of natural-product-like tnf-α inhibitors",

abstract = "(Figure Presented) Small but effective: Two natural-productlike inhibitors of tumor necrosis factor α (TNF-α represented in green in the picture) have been identified using structure-based virtual screening. These compounds represent only the third and fourth examples of direct targeting of TNF-α by a small molecule. and display potency comparable to that of the strongest TNF-α inhibitor reported to date.",

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AU - Lee, Ho Man

AU - Yang, Fang

AU - Che, Chi Ming

AU - Wong, Catherine C.L.

AU - Abagyan, Ruben

AU - Leung, Chung Hang

AU - MA, Edmond Dik Lung

PY - 2010/4/6

Y1 - 2010/4/6

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AB - (Figure Presented) Small but effective: Two natural-productlike inhibitors of tumor necrosis factor α (TNF-α represented in green in the picture) have been identified using structure-based virtual screening. These compounds represent only the third and fourth examples of direct targeting of TNF-α by a small molecule. and display potency comparable to that of the strongest TNF-α inhibitor reported to date.

KW - Drug discovery

KW - Inhibitors

KW - Natural products

KW - Tumor necrosis factor

KW - Virtual screening

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U2 - 10.1002/anie.200907360

DO - 10.1002/anie.200907360

M3 - Review article

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Structure-based discovery of natural-product-like tnf-α inhibitors

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