Structure-based discovery and development of natural products as Type II JAK2 inhibitors for the treatment of hepatitis C

Edmond Dik Lung MA; C. H. Leung; P. Chiu; Y. C. Cheng

Structure-based discovery and development of natural products as Type II JAK2 inhibitors for the treatment of hepatitis C

Edmond Dik Lung MA^*
, C. H. Leung
, P. Chiu
, Y. C. Cheng

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

1 Citation (Scopus)

Abstract

1. Hepatitis C is a highly infectious disease that imposes a high health, social and financial burden on the population in Hong Kong and worldwide.
2. A new platform for the virtual screening of JAK2 Type II inhibitors was constructed and utilised to identify amentoflavone as a lead scaffold for the development of new inhibitors.
3. Novel natural inhibitors were developed and showed anti-JAK2 activity and anti-viral activity in cellular systems.
4. The compounds potentially represent a novel therapeutic approach to the treatment of hepatitis C, and may supplement existing regimens for hard-to-treat HCV genotypes in Hong Kong.

Original language	English
Pages (from-to)	S32-S36
Number of pages	5
Journal	Hong Kong Medical Journal
Volume	22
Issue number	3, Suppl 4
Publication status	Published - Jun 2016

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title = "Structure-based discovery and development of natural products as Type II JAK2 inhibitors for the treatment of hepatitis C",

abstract = "1. Hepatitis C is a highly infectious disease that imposes a high health, social and financial burden on the population in Hong Kong and worldwide. 2. A new platform for the virtual screening of JAK2 Type II inhibitors was constructed and utilised to identify amentoflavone as a lead scaffold for the development of new inhibitors. 3. Novel natural inhibitors were developed and showed anti-JAK2 activity and anti-viral activity in cellular systems. 4. The compounds potentially represent a novel therapeutic approach to the treatment of hepatitis C, and may supplement existing regimens for hard-to-treat HCV genotypes in Hong Kong.",

author = "MA, \{Edmond Dik Lung\} and Leung, \{C. H.\} and P. Chiu and Cheng, \{Y. C.\}",

note = "Copyright: This record is sourced from MEDLINE{\textregistered}/PubMed{\textregistered}, a database of the U.S. National Library of Medicine",

year = "2016",

month = jun,

language = "English",

volume = "22",

pages = "S32--S36",

journal = "Hong Kong Medical Journal",

issn = "1024-2708",

publisher = "Hong Kong Academy of Medicine Press",

number = "3, Suppl 4",

}

TY - JOUR

T1 - Structure-based discovery and development of natural products as Type II JAK2 inhibitors for the treatment of hepatitis C

AU - MA, Edmond Dik Lung

AU - Leung, C. H.

AU - Chiu, P.

AU - Cheng, Y. C.

N1 - Copyright: This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

PY - 2016/6

Y1 - 2016/6

N2 - 1. Hepatitis C is a highly infectious disease that imposes a high health, social and financial burden on the population in Hong Kong and worldwide. 2. A new platform for the virtual screening of JAK2 Type II inhibitors was constructed and utilised to identify amentoflavone as a lead scaffold for the development of new inhibitors. 3. Novel natural inhibitors were developed and showed anti-JAK2 activity and anti-viral activity in cellular systems. 4. The compounds potentially represent a novel therapeutic approach to the treatment of hepatitis C, and may supplement existing regimens for hard-to-treat HCV genotypes in Hong Kong.

AB - 1. Hepatitis C is a highly infectious disease that imposes a high health, social and financial burden on the population in Hong Kong and worldwide. 2. A new platform for the virtual screening of JAK2 Type II inhibitors was constructed and utilised to identify amentoflavone as a lead scaffold for the development of new inhibitors. 3. Novel natural inhibitors were developed and showed anti-JAK2 activity and anti-viral activity in cellular systems. 4. The compounds potentially represent a novel therapeutic approach to the treatment of hepatitis C, and may supplement existing regimens for hard-to-treat HCV genotypes in Hong Kong.

UR - https://www.hkmj.org/abstracts/v22n3%20Suppl%204/32.htm

UR - https://www.scopus.com/pages/publications/85040979507

M3 - Journal article

C2 - 27390008

AN - SCOPUS:85040979507

SN - 1024-2708

VL - 22

SP - S32-S36

JO - Hong Kong Medical Journal

JF - Hong Kong Medical Journal

IS - 3, Suppl 4

ER -

Structure-based discovery and development of natural products as Type II JAK2 inhibitors for the treatment of hepatitis C

Abstract

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