Structure and stability of hexadentate complexes of ligands based on AAZTA for efficient PET labelling with gallium-68

Bradley P. Waldron; David Parker; Carsten Burchardt; Dmitry S. Yufit; Melanie Zimny; Frank Roesch

doi:10.1039/c2cc37544c

Structure and stability of hexadentate complexes of ligands based on AAZTA for efficient PET labelling with gallium-68

Bradley P. Waldron
, David Parker^*
, Carsten Burchardt
, Dmitry S. Yufit
, Melanie Zimny
, Frank Roesch

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

75 Citations (Scopus)

Abstract

Pre-organised tricarboxylate ligands based on 6-amino-perhydro-1,4-diazepine bind ⁶⁸Ga rapidly and selectively in acetate buffer at pH 4 to 7, forming kinetically stable complexes suitable for use in PET imaging.

Original language	English
Pages (from-to)	579-581
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	6
Early online date	14 Nov 2012
DOIs	https://doi.org/10.1039/c2cc37544c
Publication status	Published - 21 Jan 2013

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10.1039/c2cc37544c

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title = "Structure and stability of hexadentate complexes of ligands based on AAZTA for efficient PET labelling with gallium-68",

abstract = "Pre-organised tricarboxylate ligands based on 6-amino-perhydro-1,4-diazepine bind 68Ga rapidly and selectively in acetate buffer at pH 4 to 7, forming kinetically stable complexes suitable for use in PET imaging.",

author = "Waldron, \{Bradley P.\} and David Parker and Carsten Burchardt and Yufit, \{Dmitry S.\} and Melanie Zimny and Frank Roesch",

note = "We thank the Association of Commonwealth Universities for a scholarship (BPW) and ESF COST Action D38 for support. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2013",

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language = "English",

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journal = "Chemical Communications",

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T1 - Structure and stability of hexadentate complexes of ligands based on AAZTA for efficient PET labelling with gallium-68

AU - Waldron, Bradley P.

AU - Parker, David

AU - Burchardt, Carsten

AU - Yufit, Dmitry S.

AU - Zimny, Melanie

AU - Roesch, Frank

PY - 2013/1/21

Y1 - 2013/1/21

N2 - Pre-organised tricarboxylate ligands based on 6-amino-perhydro-1,4-diazepine bind 68Ga rapidly and selectively in acetate buffer at pH 4 to 7, forming kinetically stable complexes suitable for use in PET imaging.

AB - Pre-organised tricarboxylate ligands based on 6-amino-perhydro-1,4-diazepine bind 68Ga rapidly and selectively in acetate buffer at pH 4 to 7, forming kinetically stable complexes suitable for use in PET imaging.

UR - https://www.scopus.com/pages/publications/84871266281

UR - https://pubs.rsc.org/en/content/articlelanding/2013/cc/c2cc37544c

U2 - 10.1039/c2cc37544c

DO - 10.1039/c2cc37544c

M3 - Journal article

AN - SCOPUS:84871266281

SN - 1359-7345

VL - 49

SP - 579

EP - 581

JO - Chemical Communications

JF - Chemical Communications

IS - 6

ER -

Structure and stability of hexadentate complexes of ligands based on AAZTA for efficient PET labelling with gallium-68

Abstract

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