Structure and relaxivity of macrocyclic gadolinium complexes incorporating pyridyl and 4-morpholinopyridyl substituents

Silvio Aime; Andrei S. Batsanov; Mauro Botta; Judith A.K. Howard; Mark P. Lowe; David Parker

doi:10.1039/a901704f

Structure and relaxivity of macrocyclic gadolinium complexes incorporating pyridyl and 4-morpholinopyridyl substituents

Silvio Aime^*
, Andrei S. Batsanov
, Mauro Botta
, Judith A.K. Howard
, Mark P. Lowe
, David Parker

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

40 Citations (Scopus)

Abstract

Octadentate N₅O₃ ligands containing a coordinating pyridyl group form kinetically stable complexes with Eu and Gd that resist protonation; the structure of a representative Gd complex reveals a short Gd–N_py bond [2.535(1) Å], and the water exchange rate (k_ex²⁹⁸=2.7×10⁶ s^-1) is sufficiently fast so as not to limit the pH independent relaxivity (R_1p²⁹⁸=5.3 mM^-1 s^-1, 20 MHz).

Original language	English
Pages (from-to)	669-670
Number of pages	2
Journal	New Journal of Chemistry
Volume	23
Issue number	7
DOIs	https://doi.org/10.1039/a901704f
Publication status	Published - Jul 1999

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@article{9853a7e987b94eafb371ae4ce9481007,

title = "Structure and relaxivity of macrocyclic gadolinium complexes incorporating pyridyl and 4-morpholinopyridyl substituents",

abstract = "Octadentate N5O3 ligands containing a coordinating pyridyl group form kinetically stable complexes with Eu and Gd that resist protonation; the structure of a representative Gd complex reveals a short Gd–Npy bond [2.535(1) {\AA}], and the water exchange rate (kex298=2.7×106 s-1) is sufficiently fast so as not to limit the pH independent relaxivity (R1p298=5.3 mM-1 s-1, 20 MHz).",

author = "Silvio Aime and Batsanov, \{Andrei S.\} and Mauro Botta and Howard, \{Judith A.K.\} and Lowe, \{Mark P.\} and David Parker",

year = "1999",

month = jul,

doi = "10.1039/a901704f",

language = "English",

volume = "23",

pages = "669--670",

journal = "New Journal of Chemistry",

issn = "1144-0546",

publisher = "Royal Society of Chemistry",

number = "7",

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TY - JOUR

T1 - Structure and relaxivity of macrocyclic gadolinium complexes incorporating pyridyl and 4-morpholinopyridyl substituents

AU - Aime, Silvio

AU - Batsanov, Andrei S.

AU - Botta, Mauro

AU - Howard, Judith A.K.

AU - Lowe, Mark P.

AU - Parker, David

PY - 1999/7

Y1 - 1999/7

N2 - Octadentate N5O3 ligands containing a coordinating pyridyl group form kinetically stable complexes with Eu and Gd that resist protonation; the structure of a representative Gd complex reveals a short Gd–Npy bond [2.535(1) Å], and the water exchange rate (kex298=2.7×106 s-1) is sufficiently fast so as not to limit the pH independent relaxivity (R1p298=5.3 mM-1 s-1, 20 MHz).

AB - Octadentate N5O3 ligands containing a coordinating pyridyl group form kinetically stable complexes with Eu and Gd that resist protonation; the structure of a representative Gd complex reveals a short Gd–Npy bond [2.535(1) Å], and the water exchange rate (kex298=2.7×106 s-1) is sufficiently fast so as not to limit the pH independent relaxivity (R1p298=5.3 mM-1 s-1, 20 MHz).

UR - https://www.scopus.com/pages/publications/0032798407

U2 - 10.1039/a901704f

DO - 10.1039/a901704f

M3 - Journal article

AN - SCOPUS:0032798407

SN - 1144-0546

VL - 23

SP - 669

EP - 670

JO - New Journal of Chemistry

JF - New Journal of Chemistry

IS - 7

ER -

Structure and relaxivity of macrocyclic gadolinium complexes incorporating pyridyl and 4-morpholinopyridyl substituents

Abstract

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