Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha

Rong Tao Li; Quan Bin Han; Yong Tang Zheng; Rui Rui Wang; Liu Meng Yang; Yang Lu; Su Qin Sang; Qi Tai Zheng; Qin Shi Zhao; Han Dong Sun

doi:10.1039/b501932j

Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha

Rong Tao Li
, Quan Bin Han
, Yong Tang Zheng
, Rui Rui Wang
, Liu Meng Yang
, Yang Lu
, Su Qin Sang
, Qi Tai Zheng
, Qin Shi Zhao
, Han Dong Sun^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

107 Citations (Scopus)

Abstract

Two new highly oxygenated nortriterpenoids with a unique norcycloartane skeleton, micrandilactones B and C (1-2), were isolated from Schisandra micrantha; micrandilactone C (2) exhibited an EC₅₀ value of 7.71 μg/mL (SI > 25.94) against HIV-1 replication with minimal cytotoxicity, and the potent anti-HIV-1 activity and unique structural features of 2 make it a promising lead for therapeutic development of a new generation of anti-HIV drug.

Original language	English
Pages (from-to)	2936-2938
Number of pages	3
Journal	Chemical Communications
Issue number	23
Early online date	26 Apr 2005
DOIs	https://doi.org/10.1039/b501932j
Publication status	Published - 21 Jun 2005

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10.1039/b501932j

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title = "Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha",

abstract = "Two new highly oxygenated nortriterpenoids with a unique norcycloartane skeleton, micrandilactones B and C (1-2), were isolated from Schisandra micrantha; micrandilactone C (2) exhibited an EC50 value of 7.71 μg/mL (SI > 25.94) against HIV-1 replication with minimal cytotoxicity, and the potent anti-HIV-1 activity and unique structural features of 2 make it a promising lead for therapeutic development of a new generation of anti-HIV drug.",

author = "Li, \{Rong Tao\} and Han, \{Quan Bin\} and Zheng, \{Yong Tang\} and Wang, \{Rui Rui\} and Yang, \{Liu Meng\} and Yang Lu and Sang, \{Su Qin\} and Zheng, \{Qi Tai\} and Zhao, \{Qin Shi\} and Sun, \{Han Dong\}",

note = "This work was supported by grants from the National Natural Science Foundation of China (20402016) to Dr R. T. Li; the Key Scientific and Technological projects of Yunnan (2004NG12), CAS Knowledge Innovation Projects (KSCX2-SW-216), and National 863 Program (2003AA219142) to Dr Y. T. Zheng.",

year = "2005",

month = jun,

day = "21",

doi = "10.1039/b501932j",

language = "English",

pages = "2936--2938",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "23",

}

TY - JOUR

T1 - Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha

AU - Li, Rong Tao

AU - Han, Quan Bin

AU - Zheng, Yong Tang

AU - Wang, Rui Rui

AU - Yang, Liu Meng

AU - Lu, Yang

AU - Sang, Su Qin

AU - Zheng, Qi Tai

AU - Zhao, Qin Shi

AU - Sun, Han Dong

N1 - This work was supported by grants from the National Natural Science Foundation of China (20402016) to Dr R. T. Li; the Key Scientific and Technological projects of Yunnan (2004NG12), CAS Knowledge Innovation Projects (KSCX2-SW-216), and National 863 Program (2003AA219142) to Dr Y. T. Zheng.

PY - 2005/6/21

Y1 - 2005/6/21

N2 - Two new highly oxygenated nortriterpenoids with a unique norcycloartane skeleton, micrandilactones B and C (1-2), were isolated from Schisandra micrantha; micrandilactone C (2) exhibited an EC50 value of 7.71 μg/mL (SI > 25.94) against HIV-1 replication with minimal cytotoxicity, and the potent anti-HIV-1 activity and unique structural features of 2 make it a promising lead for therapeutic development of a new generation of anti-HIV drug.

AB - Two new highly oxygenated nortriterpenoids with a unique norcycloartane skeleton, micrandilactones B and C (1-2), were isolated from Schisandra micrantha; micrandilactone C (2) exhibited an EC50 value of 7.71 μg/mL (SI > 25.94) against HIV-1 replication with minimal cytotoxicity, and the potent anti-HIV-1 activity and unique structural features of 2 make it a promising lead for therapeutic development of a new generation of anti-HIV drug.

UR - https://www.scopus.com/pages/publications/21444434074

U2 - 10.1039/b501932j

DO - 10.1039/b501932j

M3 - Journal article

SN - 1359-7345

SP - 2936

EP - 2938

JO - Chemical Communications

JF - Chemical Communications

IS - 23

ER -

Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha

Abstract

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