Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha

Rong Tao Li; Quan Bin Han; Yong Tang Zheng; Rui Rui Wang; Liu Meng Yang; Yang Lu; Su Qin Sang; Qi Tai Zheng; Qin Shi Zhao; Han Dong Sun

doi:10.1039/b501932j

Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha

Rong Tao Li, Quan Bin Han, Yong Tang Zheng, Rui Rui Wang, Liu Meng Yang, Yang Lu, Su Qin Sang, Qi Tai Zheng, Qin Shi Zhao, Han Dong Sun^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

106 Citations (Scopus)

Abstract

Two new highly oxygenated nortriterpenoids with a unique norcycloartane skeleton, micrandilactones B and C (1-2), were isolated from Schisandra micrantha; micrandilactone C (2) exhibited an EC₅₀ value of 7.71 μg/mL (SI > 25.94) against HIV-1 replication with minimal cytotoxicity, and the potent anti-HIV-1 activity and unique structural features of 2 make it a promising lead for therapeutic development of a new generation of anti-HIV drug.

Original language	English
Pages (from-to)	2936-2938
Number of pages	3
Journal	Chemical Communications
Issue number	23
Early online date	26 Apr 2005
DOIs	https://doi.org/10.1039/b501932j
Publication status	Published - 21 Jun 2005

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title = "Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha",

abstract = "Two new highly oxygenated nortriterpenoids with a unique norcycloartane skeleton, micrandilactones B and C (1-2), were isolated from Schisandra micrantha; micrandilactone C (2) exhibited an EC50 value of 7.71 μg/mL (SI > 25.94) against HIV-1 replication with minimal cytotoxicity, and the potent anti-HIV-1 activity and unique structural features of 2 make it a promising lead for therapeutic development of a new generation of anti-HIV drug.",

author = "Li, {Rong Tao} and Han, {Quan Bin} and Zheng, {Yong Tang} and Wang, {Rui Rui} and Yang, {Liu Meng} and Yang Lu and Sang, {Su Qin} and Zheng, {Qi Tai} and Zhao, {Qin Shi} and Sun, {Han Dong}",

year = "2005",

month = jun,

day = "21",

doi = "10.1039/b501932j",

language = "English",

pages = "2936--2938",

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issn = "1359-7345",

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TY - JOUR

T1 - Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha

AU - Li, Rong Tao

AU - Han, Quan Bin

AU - Zheng, Yong Tang

AU - Wang, Rui Rui

AU - Yang, Liu Meng

AU - Lu, Yang

AU - Sang, Su Qin

AU - Zheng, Qi Tai

AU - Zhao, Qin Shi

AU - Sun, Han Dong

PY - 2005/6/21

Y1 - 2005/6/21

N2 - Two new highly oxygenated nortriterpenoids with a unique norcycloartane skeleton, micrandilactones B and C (1-2), were isolated from Schisandra micrantha; micrandilactone C (2) exhibited an EC50 value of 7.71 μg/mL (SI > 25.94) against HIV-1 replication with minimal cytotoxicity, and the potent anti-HIV-1 activity and unique structural features of 2 make it a promising lead for therapeutic development of a new generation of anti-HIV drug.

AB - Two new highly oxygenated nortriterpenoids with a unique norcycloartane skeleton, micrandilactones B and C (1-2), were isolated from Schisandra micrantha; micrandilactone C (2) exhibited an EC50 value of 7.71 μg/mL (SI > 25.94) against HIV-1 replication with minimal cytotoxicity, and the potent anti-HIV-1 activity and unique structural features of 2 make it a promising lead for therapeutic development of a new generation of anti-HIV drug.

UR - http://www.scopus.com/inward/record.url?scp=21444434074&partnerID=8YFLogxK

U2 - 10.1039/b501932j

DO - 10.1039/b501932j

M3 - Journal article

SN - 1359-7345

SP - 2936

EP - 2938

JO - Chemical Communications

JF - Chemical Communications

IS - 23

ER -

Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha

Abstract

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