Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha

Rong Tao Li, Quan Bin Han, Yong Tang Zheng, Rui Rui Wang, Liu Meng Yang, Yang Lu, Su Qin Sang, Qi Tai Zheng, Qin Shi Zhao, Han Dong Sun*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

105 Citations (Scopus)

Abstract

Two new highly oxygenated nortriterpenoids with a unique norcycloartane skeleton, micrandilactones B and C (1-2), were isolated from Schisandra micrantha; micrandilactone C (2) exhibited an EC50 value of 7.71 μg/mL (SI > 25.94) against HIV-1 replication with minimal cytotoxicity, and the potent anti-HIV-1 activity and unique structural features of 2 make it a promising lead for therapeutic development of a new generation of anti-HIV drug.

Original languageEnglish
Pages (from-to)2936-2938
Number of pages3
JournalChemical Communications
Issue number23
Early online date26 Apr 2005
DOIs
Publication statusPublished - 21 Jun 2005

Scopus Subject Areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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