TY - JOUR
T1 - Strategies for combination of aptamer and targeted drug delivery
AU - Wang, Cheng
AU - Liu, Biao
AU - Lu, Jun
AU - ZHANG, Ge
AU - LYU, Aiping
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/1
Y1 - 2014/1
N2 - Cell-specific delivery of active agents for treatment of human disease is a long cherished object for scientific researchers. Nanoscience generated nanosized carriers, such as liposome, micelle and nanoparticle, provides potential to realize such purpose based on the nanometer size effect (<1000 nm), however, the sole nanocarrier with no specific ligands are not sufficient to deliver drugs to target sites. Aptamers are single-stranded oligonucleotides which can specifically recognize and bind to target cells by distinct secondary and tertiary structures even without knowledge of characteristic protein profiles on cell surface. Thus, aptamer, as a target moiety, provides a potential approach to realize pathological site-specific delivery of active agents. This review highlighted the strategies for combination of aptamer and targeted drug delivery, further summarized their preparation methods, strengths and weaknesses to facilitate the development of targeted drug delivery system.
AB - Cell-specific delivery of active agents for treatment of human disease is a long cherished object for scientific researchers. Nanoscience generated nanosized carriers, such as liposome, micelle and nanoparticle, provides potential to realize such purpose based on the nanometer size effect (<1000 nm), however, the sole nanocarrier with no specific ligands are not sufficient to deliver drugs to target sites. Aptamers are single-stranded oligonucleotides which can specifically recognize and bind to target cells by distinct secondary and tertiary structures even without knowledge of characteristic protein profiles on cell surface. Thus, aptamer, as a target moiety, provides a potential approach to realize pathological site-specific delivery of active agents. This review highlighted the strategies for combination of aptamer and targeted drug delivery, further summarized their preparation methods, strengths and weaknesses to facilitate the development of targeted drug delivery system.
KW - Aptamer
KW - Liposome
KW - Micelle
KW - Nanocarrier
KW - Nanoparticle
KW - Targeted Drug Delivery
UR - http://www.scopus.com/inward/record.url?scp=84893761232&partnerID=8YFLogxK
U2 - 10.1166/jnn.2014.8746
DO - 10.1166/jnn.2014.8746
M3 - Review article
C2 - 24730278
AN - SCOPUS:84893761232
SN - 1533-4880
VL - 14
SP - 501
EP - 512
JO - Journal of Nanoscience and Nanotechnology
JF - Journal of Nanoscience and Nanotechnology
IS - 1
ER -