Steric control of lanthanide hydration state: Fast water exchange at gadolinium in a mono-amide 'DOTA' complex

Aileen Congreve; David Parker; Eliana Gianolio; Mauro Botta

doi:10.1039/B402230K

Steric control of lanthanide hydration state: Fast water exchange at gadolinium in a mono-amide 'DOTA' complex

Aileen Congreve, David Parker^*, Eliana Gianolio, Mauro Botta

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

41 Citations (Scopus)

Abstract

Detailed analyses of the solution structure and exchange dynamics of two sets of homologous mono-amide triacetate lanthanide complexes (Ln = Eu, Gd) of cyclen have been undertaken. The complex [LnL¹], bearing an N-linked CH₂CH₂NHCO-pyridyl moiety, forms mono-aqua (q = 1) species in solution and the Gd complex undergoes rapid water exchange (k_ex = 11 × 10⁷s^-1, 298 K) as a result of the steric destabilisation of the Ln-water binding interaction. The homologous complex with a C-3 spacing chain, [LnL²], forms a q = 0 species.

Original language	English
Pages (from-to)	1441-1445
Number of pages	5
Journal	Dalton Transactions
Issue number	9
DOIs	https://doi.org/10.1039/B402230K
Publication status	Published - 5 Apr 2004

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abstract = "Detailed analyses of the solution structure and exchange dynamics of two sets of homologous mono-amide triacetate lanthanide complexes (Ln = Eu, Gd) of cyclen have been undertaken. The complex [LnL1], bearing an N-linked CH2CH2NHCO-pyridyl moiety, forms mono-aqua (q = 1) species in solution and the Gd complex undergoes rapid water exchange (kex = 11 × 107s-1, 298 K) as a result of the steric destabilisation of the Ln-water binding interaction. The homologous complex with a C-3 spacing chain, [LnL2], forms a q = 0 species.",

author = "Aileen Congreve and David Parker and Eliana Gianolio and Mauro Botta",

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T1 - Steric control of lanthanide hydration state

T2 - Fast water exchange at gadolinium in a mono-amide 'DOTA' complex

AU - Congreve, Aileen

AU - Parker, David

AU - Gianolio, Eliana

AU - Botta, Mauro

N1 - We thank EPSRC and ONE NE for support and ESF-COST D18 for promoting this collaborative work

PY - 2004/4/5

Y1 - 2004/4/5

N2 - Detailed analyses of the solution structure and exchange dynamics of two sets of homologous mono-amide triacetate lanthanide complexes (Ln = Eu, Gd) of cyclen have been undertaken. The complex [LnL1], bearing an N-linked CH2CH2NHCO-pyridyl moiety, forms mono-aqua (q = 1) species in solution and the Gd complex undergoes rapid water exchange (kex = 11 × 107s-1, 298 K) as a result of the steric destabilisation of the Ln-water binding interaction. The homologous complex with a C-3 spacing chain, [LnL2], forms a q = 0 species.

AB - Detailed analyses of the solution structure and exchange dynamics of two sets of homologous mono-amide triacetate lanthanide complexes (Ln = Eu, Gd) of cyclen have been undertaken. The complex [LnL1], bearing an N-linked CH2CH2NHCO-pyridyl moiety, forms mono-aqua (q = 1) species in solution and the Gd complex undergoes rapid water exchange (kex = 11 × 107s-1, 298 K) as a result of the steric destabilisation of the Ln-water binding interaction. The homologous complex with a C-3 spacing chain, [LnL2], forms a q = 0 species.

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JO - Dalton Transactions

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Steric control of lanthanide hydration state: Fast water exchange at gadolinium in a mono-amide 'DOTA' complex

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