Squalene Epoxidase Induces Nonalcoholic Steatohepatitis Via Binding to Carbonic Anhydrase III and is a Therapeutic Target

Keyphrases

• Therapeutic Target 100%
• Nonalcoholic Steatohepatitis 100%
• Squalene Epoxidase 100%
• Carbonic Anhydrase III 100%
• Overexpression 14%
• Transgenic Mice 14%
• High-fat Diet 14%
• Methionine 14%
• High Cholesterol 14%
• Terbinafine 14%
• Healthy Controls 14%
• Cholesterol Biosynthesis 14%
• Choline-deficient 14%
• Acetazolamide 14%
• Combined Targeting 14%
• Insulin Resistance 7%
• Molecular Mechanism 7%
• Confidence Interval 7%
• Therapeutic Effect 7%
• Western Blot 7%
• Hepatocyte-specific 7%
• Nuclear factor-B 7%
• Co-immunoprecipitation (co-IP) 7%
• Functional Significance 7%
• Hepatic Steatosis 7%
• Lipogenesis 7%
• Hepatic Cholesterol 7%
• Mouse Model 7%
• Liver Tissue 7%
• Sterol Regulatory Element-binding protein-1c (SREBP-1c) 7%
• Fatty Acid Synthase 7%
• Liver Injury 7%
• Novel Biomarkers 7%
• Human Samples 7%
• Steatosis 7%
• Rate-limiting Enzyme 7%
• Therapeutic Benefits 7%
• Area under the Receiver Operating Characteristic Curve 7%
• Cholesterol Accumulation 7%
• Downstream Targets 7%
• Control Area 7%
• Steatohepatitis 7%
• Clinical Impact 7%
• Acetyl-CoA Carboxylase 7%
• Non-invasive Diagnosis 7%
• Tg Mouse 7%
• Hepatic Lipogenesis 7%
• Squalene Epoxidase Inhibitors 7%
• Stearoyl-CoA 7%

Medicine and Dentistry

• Nonalcoholic Fatty Liver 100%
• Squalene Monooxygenase 100%
• Carbonate Dehydratase III 100%
• Transgenic Mouse 13%
• Lipogenesis 13%
• Hypercholesterolemia 13%
• Terbinafine 13%
• Cholesterol Synthesis 13%
• Acetazolamide 13%
• Biological Marker 6%
• Nuclear Factor 6%
• Alternative Complement Pathway C3 C5 Convertase 6%
• Western Blot 6%
• Therapy Effect 6%
• Insulin Resistance 6%
• Liver Injury 6%
• Fatty Liver 6%
• Hepatocyte 6%
• Steatosis 6%
• Fatty Acid Synthase 6%
• Steatohepatitis 6%
• Acetyl-CoA 6%
• Choline 6%
• Immunoprecipitation 6%
• Liver Tissue 6%
• Methionine/Choline Deficient Diet 6%
• Methionine 6%
• Sterol Regulatory Element Binding Protein 1c 6%
• Carboxylase 6%
• Stearoyl-CoA 6%

Pharmacology, Toxicology and Pharmaceutical Science

• Nonalcoholic Fatty Liver 100%
• Squalene Monooxygenase 100%
• Carbonate Dehydratase III 100%
• Transgenic Mouse 13%
• Hypercholesterolemia 13%
• Terbinafine 13%
• Methionine 13%
• Choline 13%
• Acetazolamide 13%
• Insulin Resistance 6%
• Mouse Model 6%
• Biological Marker 6%
• Therapeutic Effect 6%
• Western Blot 6%
• Nuclear Factor 6%
• Fatty Liver 6%
• Alternative Complement Pathway C3 C5 Convertase 6%
• Liver Injury 6%
• Fatty Acid Synthase 6%
• Immunoprecipitation 6%
• Steatosis 6%
• Acetyl-CoA 6%
• Sterol Regulatory Element Binding Protein 1c 6%
• Carboxylase 6%
• Nutritional Deficiency 6%
• Stearoyl-CoA 6%