Spectrometric studies of cytotoxic protoberberine alkaloids binding to double-stranded DNA

Keyphrases

• Single-stranded DNA (ssDNA) 100%
• Berberine 100%
• Spectrometric Studies 100%
• Protoberberine Alkaloids 100%
• Palmatine 70%
• Coptisine 70%
• Electrospray Ionization 50%
• Berberrubine 50%
• Jatrorrhizine 40%
• Alkaloids 40%
• Fluorescence Titration 30%
• Association Constant 30%
• Sequence Selectivity 30%
• Relative Binding Affinity 30%
• AT-rich DNA 20%
• Binding Preference 20%
• Titration Experiment 20%
• Noncovalent Complexes 10%
• Full Agreement 10%
• No Significant Difference 10%
• Hoechst 33258 10%
• Competitive Binding 10%
• Oligodeoxynucleotide 10%
• Solution Conditions 10%
• DNA Minor Groove Binder 10%
• Binding Stoichiometry 10%
• Structure-activity Relationship 10%
• Complex Signal 10%
• AT-rich 10%
• GC-rich DNA 10%
• GC-rich Sequence 10%
• Binding Experiment 10%
• Double Helical 10%
• Double Strand 10%
• Mass Titration 10%
• Spectrometric Method 10%
• Titration Method 10%
• Mass Spectrometric Studies 10%
• DNA Binding 10%
• Duplex 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Double Stranded DNA 100%
• Berberine 100%
• Protoberberine 100%
• Palmatine 70%
• Coptisine 70%
• Beroline 50%
• Electrospray Ionization 50%
• Jatrorrhizine 40%
• Preference 20%
• Structure Activity Relationship 10%
• Oligodeoxynucleotide 10%
• 4 [5 (4 Methyl 1 piperazinyl)[2,5' Bi 1h Benzimidazol] 2' Yl]phenol 10%

Chemistry

• Double-Stranded DNA 100%
• Berberine 100%
• Coptisine 70%
• Palmatine 70%
• Electrospray Ionization 50%
• Jatrorrhizine 40%
• DNA 30%
• Kd 30%
• Association Constant 30%
• Fluorescence Spectroscopy 10%
• Structure-Activity Relationship 10%
• Reaction Stoichiometry 10%
• DNA Binding 10%