Spectral imaging in microscopy aids evaluation of the luminescent probe behaviour of europium complexes

Huishan Li, David Parker*, Jing Xiang Zhang, Hongguang Li*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

2 Citations (Scopus)

Abstract

In a series of structurally related cationic Eu(III) triamide complexes, the analysis of variations in emission lifetime and spectral signature as a function of probe environment has elucidated the nature of changes to probe speciation. The cationic complexes exhibit an intrinsic tendency to localise in cellular nucleoli or the lysosomes, providing key information in the design and evaluation of related targeted probes. Each of the three complexes studied possesses a coordinated water molecule in aqueous media, that is absent in organic solvents or is displaced by the addition of protein. The complex observed in cellulo is probably a protein-bound Eu complex.

Original languageEnglish
Article number119852
JournalJournal of Luminescence
Volume260
DOIs
Publication statusPublished - Aug 2023

Scopus Subject Areas

  • Biophysics
  • Atomic and Molecular Physics, and Optics
  • General Chemistry
  • Biochemistry
  • Condensed Matter Physics

User-Defined Keywords

  • Emissive lanthanide probes
  • Luminescent probe
  • Protein-bound Eu complex
  • Spectral imaging

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