Specific blocking of CREB/DNA binding by cyclometalated platinum(II) complexes

Ping Wang, Chung Hang Leung, Edmond Dik Lung MA, Raymond Wai Yin Sun, Siu Cheong Yan, Qing Shou Chen, Chi Ming Che*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)

Abstract

In the groove: The unique major-groove-binding properties of a Pt II complex can be used to block the interaction between the transcription factor CREB and DNA (see picture). Variation of the ligands around the Pt II center changes the DNA binding mode and results in specific gene regulators with superior potency and selectivity.

Original languageEnglish
Pages (from-to)2554-2558
Number of pages5
JournalAngewandte Chemie. International Edition
Volume50
Issue number11
DOIs
Publication statusPublished - 7 Mar 2011

Scopus Subject Areas

  • Catalysis
  • Chemistry(all)

User-Defined Keywords

  • bioinorganic chemistry
  • DNA recognition
  • metallodrugs
  • platinum
  • transcription factors

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