Specific blocking of CREB/DNA binding by cyclometalated platinum(II) complexes

Ping Wang; Chung Hang Leung; Dik Lung Ma; Raymond Wai Yin Sun; Siu Cheong Yan; Qing Shou Chen; Chi Ming Che

doi:10.1002/anie.201006887

Specific blocking of CREB/DNA binding by cyclometalated platinum(II) complexes

Ping Wang, Chung Hang Leung, Dik Lung Ma, Raymond Wai Yin Sun, Siu Cheong Yan, Qing Shou Chen, Chi Ming Che^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

54 Citations (Scopus)

Abstract

In the groove: The unique major-groove-binding properties of a Pt ^II complex can be used to block the interaction between the transcription factor CREB and DNA (see picture). Variation of the ligands around the Pt ^II center changes the DNA binding mode and results in specific gene regulators with superior potency and selectivity.

Original language	English
Pages (from-to)	2554-2558
Number of pages	5
Journal	Angewandte Chemie. International Edition
Volume	50
Issue number	11
DOIs	https://doi.org/10.1002/anie.201006887
Publication status	Published - 7 Mar 2011

Scopus Subject Areas

Catalysis
General Chemistry

User-Defined Keywords

bioinorganic chemistry
DNA recognition
metallodrugs
platinum
transcription factors

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10.1002/anie.201006887

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abstract = "In the groove: The unique major-groove-binding properties of a Pt II complex can be used to block the interaction between the transcription factor CREB and DNA (see picture). Variation of the ligands around the Pt II center changes the DNA binding mode and results in specific gene regulators with superior potency and selectivity.",

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author = "Ping Wang and Leung, {Chung Hang} and Ma, {Dik Lung} and Sun, {Raymond Wai Yin} and Yan, {Siu Cheong} and Chen, {Qing Shou} and Che, {Chi Ming}",

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AU - Yan, Siu Cheong

AU - Chen, Qing Shou

AU - Che, Chi Ming

PY - 2011/3/7

Y1 - 2011/3/7

N2 - In the groove: The unique major-groove-binding properties of a Pt II complex can be used to block the interaction between the transcription factor CREB and DNA (see picture). Variation of the ligands around the Pt II center changes the DNA binding mode and results in specific gene regulators with superior potency and selectivity.

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KW - DNA recognition

KW - metallodrugs

KW - platinum

KW - transcription factors

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M3 - Journal article

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Specific blocking of CREB/DNA binding by cyclometalated platinum(II) complexes

Abstract

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