Spatial and chronic differences in neural activity in medicated and unmedicated schizophrenia patients

Zachary Adam Yaple, Serenella Tolomeo, Rongjun Yu*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review


A major caveat with investigations on schizophrenic patients is the difficulty to control for medication usage across samples as disease-related neural differences may be confounded by medication usage. Following a thorough literature search (632 records identified), we included 37 studies with a total of 740 medicated schizophrenia patients and 367 unmedicated schizophrenia patients. Here, we perform several meta-analyses to assess the neurofunctional differences between medicated and unmedicated schizophrenic patients across fMRI studies to determine systematic regions associated with medication usage. Several clusters identified by the meta-analysis on the medicated group include three right lateralized frontal clusters and a left lateralized parietal cluster, whereas the unmedicated group yielded concordant activity among right lateralized frontal-parietal regions. We further explored the prevalence of activity within these regions across illness duration and task type. These findings suggest a neural compensatory mechanism across these regions both spatially and chronically, offering new insight into the spatial and temporal dynamic neural differences among medicated and unmedicated schizophrenia patients.

Original languageEnglish
Article number103029
JournalNeuroImage: Clinical
Publication statusPublished - 12 May 2022

Scopus Subject Areas

  • Clinical Neurology
  • Neurology
  • Cognitive Neuroscience
  • Radiology Nuclear Medicine and imaging

User-Defined Keywords

  • fMRI meta-analysis
  • Medication
  • Schizophrenia


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