TY - JOUR
T1 - Sophisticated crosstalk of tryptophan-derived metabolites in plant stress responses
AU - Wang, Shuang
AU - Zhang, Xia
AU - Gong, Dao-Hong
AU - Huang, Qiu-Qian
AU - Kandegama, W.M.W.W.
AU - Georgiev, Milen I.
AU - Gao, Yang-Yang
AU - Liao, Pan
AU - Hao, Ge-Fei
N1 - This work was supported by the National Key Research and Development Program of China (No. 2024YFE0214300), the National Natural Science Foundation of China (32125033, 32260687), and the Central Government Guides Local Science and Technology Development Fund Projects (Qiankehezhongyindi (2023) 001). M.I.G. acknowledges financial support from the European Union's Horizon 2020 research and innovation programme, project PlantaSYST (SGA No 739582 under FPA No.664620), and the BG05M2OP001-1.003-001-C01 project, financed by the European Regional Development Fund through the "Science and Education for Smart Growth" Operational Programme. L.P. acknowledges financial support from the Department Start-up fund of Hong Kong Baptist University (BIOL-22-23-01), Faculty Niche Research Areas 2022/23 (RC-FNRA-IG/22-23/SCI/01), Hong Kong Research Grants Council (RGC) Early Career Scheme (22100923) and the National Natural Science Foundation of China/RGC Joint Research Scheme (N_HKBU201_23), the PROCORE-France/HK Joint Research Scheme (F-HKBU201/23) and Innovation and Technology Fund of Innovation Technology Commission: Funding Support to State Key Laboratory of Agrobiotechnology. Y.-Y.G. acknowledges financial support from the Science and Technology Planning Project of Guizhou Province (Qiankehejichu-ZK[2024] Key project 028) and China Postdoctoral Science Foundation (2024T170200).
Publisher Copyright:
© 2025 Published by Elsevier Inc. on behalf of CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, and Chinese Society for Plant Biology.
PY - 2025/9/8
Y1 - 2025/9/8
N2 - Plants are continuously threatened by numerous stresses that cause detrimental damage to plant health and constrain crop productivity worldwide. Metabolic regulation, hence an important tool to regulate the stress tolerance of plants. Tryptophan, as a precursor of various plant natural products, including auxin, melatonin and glucosinolates, plays crucial roles in supporting plant health. To date, remarkable progress has been made in exploring the metabolism of tryptophan, particularly its involvement in enhancing plant stress tolerance. However, there is still a lack of systematic discussion on the crosstalk manipulation of tryptophan metabolites for protecting plants from stresses. Here, we attempt to dive into the tryptophan metabolism and its related crosstalk regulation under stresses. We provide an overview of the biosynthesis and biofunctions of tryptophan metabolites with a main focus on the crosstalk manipulation of tryptophan metabolites in plant stress resistance. The perspective applications of using tryptophan metabolism under stresses are also analyzed. This work endeavors to construct a fundamental framework regarding the regulatory role of tryptophan metabolites on plant health and related mechanisms in sustainable agriculture.
AB - Plants are continuously threatened by numerous stresses that cause detrimental damage to plant health and constrain crop productivity worldwide. Metabolic regulation, hence an important tool to regulate the stress tolerance of plants. Tryptophan, as a precursor of various plant natural products, including auxin, melatonin and glucosinolates, plays crucial roles in supporting plant health. To date, remarkable progress has been made in exploring the metabolism of tryptophan, particularly its involvement in enhancing plant stress tolerance. However, there is still a lack of systematic discussion on the crosstalk manipulation of tryptophan metabolites for protecting plants from stresses. Here, we attempt to dive into the tryptophan metabolism and its related crosstalk regulation under stresses. We provide an overview of the biosynthesis and biofunctions of tryptophan metabolites with a main focus on the crosstalk manipulation of tryptophan metabolites in plant stress resistance. The perspective applications of using tryptophan metabolism under stresses are also analyzed. This work endeavors to construct a fundamental framework regarding the regulatory role of tryptophan metabolites on plant health and related mechanisms in sustainable agriculture.
KW - crosstalk regulation
KW - genetic engineering
KW - plant-environment interactions
KW - signaling pathways
KW - stress resistance
KW - tryptophan metabolism
KW - plant–environment interactions
UR - https://www.scopus.com/pages/publications/105013634348
U2 - 10.1016/j.xplc.2025.101425
DO - 10.1016/j.xplc.2025.101425
M3 - Journal article
C2 - 40545720
SN - 2590-3462
VL - 6
JO - Plant Communications
JF - Plant Communications
IS - 9
M1 - 101425
ER -
