Sonic hedgehog as a chemoattractant for adult NPCs

Catherine Hong Huan Hor, Bor Luen Tang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

The developmental morphogen Sonic hedgehog (Shh) is well known for its role in modulating the proliferation and survival of neural progenitor cells in the developing mouse brain. A recent report now showed that Shh could regulate the migration of neuroblast in the adult subventricular zone (SVZ) along the rostral migratory stream (RMS) to the olfactory bulb, by functioning as a chemoattractant. Functions of Shh in regulating the migration and survival of neural progenitor cells in the adult central nervous system are suggestive of its potential roles in neural regeneration and CNS oncogenesis.
Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalCell Adhesion and Migration
Volume4
Issue number1
DOIs
Publication statusPublished - Jan 2010

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