Small interfering RNA specific for N-Methyl-D-aspartate receptor 2B offers neuroprotection to dopamine neurons through activation of MAP kinase

Olivia T.W. Ng; L. W. Chen; Y. S. Chan; Ken K.L. Yung

doi:10.1159/000334720

Small interfering RNA specific for N-Methyl-D-aspartate receptor 2B offers neuroprotection to dopamine neurons through activation of MAP kinase

Olivia T.W. Ng, L. W. Chen, Y. S. Chan, Ken K.L. Yung^*

^*Corresponding author for this work

Department of Biology

Research output: Contribution to journal › Journal article › peer-review

4 Citations (Scopus)

Abstract

In the present study, N-methyl-D-aspartate receptor 2B (NR2B)-specific siRNA was applied in parkinsonian models. Our previous results showed that reduction in expression of N-methyl-D-aspartate receptor 1 (NR1), the key subunit of N-methyl-D-aspartate receptors, by antisense oligos amelio-rated the motor symptoms in the 6-hydroxydopamine (6-OHDA)-lesioned rat, an animal model of Parkinson's disease (PD).

Original language	English
Pages (from-to)	42-54
Number of pages	13
Journal	NeuroSignals
Volume	21
Issue number	1-2
DOIs	https://doi.org/10.1159/000334720
Publication status	Published - 2013

User-Defined Keywords

Extracellular signal-regulated kinase signaling pathway
Motor symptom
N-methyl-D-aspartate receptor 2B
Parkinson's disease
Small interference RNA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1159/000334720

Cite this

@article{8ca72ab852a1449aa3bfabe6279c1549,

title = "Small interfering RNA specific for N-Methyl-D-aspartate receptor 2B offers neuroprotection to dopamine neurons through activation of MAP kinase",

abstract = "In the present study, N-methyl-D-aspartate receptor 2B (NR2B)-specific siRNA was applied in parkinsonian models. Our previous results showed that reduction in expression of N-methyl-D-aspartate receptor 1 (NR1), the key subunit of N-methyl-D-aspartate receptors, by antisense oligos amelio-rated the motor symptoms in the 6-hydroxydopamine (6-OHDA)-lesioned rat, an animal model of Parkinson's disease (PD).",

keywords = "Extracellular signal-regulated kinase signaling pathway, Motor symptom, N-methyl-D-aspartate receptor 2B, Parkinson's disease, Small interference RNA",

author = "Ng, {Olivia T.W.} and Chen, {L. W.} and Chan, {Y. S.} and Yung, {Ken K.L.}",

year = "2013",

doi = "10.1159/000334720",

language = "English",

volume = "21",

pages = "42--54",

journal = "NeuroSignals",

issn = "1424-862X",

publisher = "Cell Physiol Biochem Press GmbH & Co KG",

number = "1-2",

}

TY - JOUR

T1 - Small interfering RNA specific for N-Methyl-D-aspartate receptor 2B offers neuroprotection to dopamine neurons through activation of MAP kinase

AU - Ng, Olivia T.W.

AU - Chen, L. W.

AU - Chan, Y. S.

AU - Yung, Ken K.L.

PY - 2013

Y1 - 2013

N2 - In the present study, N-methyl-D-aspartate receptor 2B (NR2B)-specific siRNA was applied in parkinsonian models. Our previous results showed that reduction in expression of N-methyl-D-aspartate receptor 1 (NR1), the key subunit of N-methyl-D-aspartate receptors, by antisense oligos amelio-rated the motor symptoms in the 6-hydroxydopamine (6-OHDA)-lesioned rat, an animal model of Parkinson's disease (PD).

AB - In the present study, N-methyl-D-aspartate receptor 2B (NR2B)-specific siRNA was applied in parkinsonian models. Our previous results showed that reduction in expression of N-methyl-D-aspartate receptor 1 (NR1), the key subunit of N-methyl-D-aspartate receptors, by antisense oligos amelio-rated the motor symptoms in the 6-hydroxydopamine (6-OHDA)-lesioned rat, an animal model of Parkinson's disease (PD).

KW - Extracellular signal-regulated kinase signaling pathway

KW - Motor symptom

KW - N-methyl-D-aspartate receptor 2B

KW - Parkinson's disease

KW - Small interference RNA

UR - http://www.scopus.com/inward/record.url?scp=84876141435&partnerID=8YFLogxK

U2 - 10.1159/000334720

DO - 10.1159/000334720

M3 - Journal article

C2 - 22377595

AN - SCOPUS:84876141435

SN - 1424-862X

VL - 21

SP - 42

EP - 54

JO - NeuroSignals

JF - NeuroSignals

IS - 1-2

ER -

Small interfering RNA specific for N-Methyl-D-aspartate receptor 2B offers neuroprotection to dopamine neurons through activation of MAP kinase

Abstract

User-Defined Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this