Small interfering RNA specific for N-Methyl-D-aspartate receptor 2B offers neuroprotection to dopamine neurons through activation of MAP kinase

Olivia T.W. Ng; L. W. Chen; Y. S. Chan; Ken K.L. Yung

doi:10.1159/000334720

Small interfering RNA specific for N-Methyl-D-aspartate receptor 2B offers neuroprotection to dopamine neurons through activation of MAP kinase

Olivia T.W. Ng
, L. W. Chen
, Y. S. Chan
, Ken K.L. Yung^*

^*Corresponding author for this work

Department of Biology

Research output: Contribution to journal › Journal article › peer-review

4 Citations (Scopus)

Abstract

In the present study, N-methyl-D-aspartate receptor 2B (NR2B)-specific siRNA was applied in parkinsonian models. Our previous results showed that reduction in expression of N-methyl-D-aspartate receptor 1 (NR1), the key subunit of N-methyl-D-aspartate receptors, by antisense oligos amelio-rated the motor symptoms in the 6-hydroxydopamine (6-OHDA)-lesioned rat, an animal model of Parkinson's disease (PD).

Original language	English
Pages (from-to)	42-54
Number of pages	13
Journal	NeuroSignals
Volume	21
Issue number	1-2
DOIs	https://doi.org/10.1159/000334720
Publication status	Published - 2013

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

User-Defined Keywords

Extracellular signal-regulated kinase signaling pathway
Motor symptom
N-methyl-D-aspartate receptor 2B
Parkinson's disease
Small interference RNA

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10.1159/000334720

Cite this

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title = "Small interfering RNA specific for N-Methyl-D-aspartate receptor 2B offers neuroprotection to dopamine neurons through activation of MAP kinase",

abstract = "In the present study, N-methyl-D-aspartate receptor 2B (NR2B)-specific siRNA was applied in parkinsonian models. Our previous results showed that reduction in expression of N-methyl-D-aspartate receptor 1 (NR1), the key subunit of N-methyl-D-aspartate receptors, by antisense oligos amelio-rated the motor symptoms in the 6-hydroxydopamine (6-OHDA)-lesioned rat, an animal model of Parkinson's disease (PD).",

keywords = "Extracellular signal-regulated kinase signaling pathway, Motor symptom, N-methyl-D-aspartate receptor 2B, Parkinson's disease, Small interference RNA",

author = "Ng, \{Olivia T.W.\} and Chen, \{L. W.\} and Chan, \{Y. S.\} and Yung, \{Ken K.L.\}",

note = "The present project was supported by Hong Kong Baptist University Research Committee Mini-Area of Excellence Scheme (RC/AOE/08-09/02) and General Research Fund, Hong Kong Research Grants Council (HKBU 262107 and HKBU 262210). The present work was also partially supported by the Area of Excellence Scheme established under the University Grants Committee of the HKSAR (Project No. AoE/B-15/01). ",

year = "2013",

doi = "10.1159/000334720",

language = "English",

volume = "21",

pages = "42--54",

journal = "NeuroSignals",

issn = "1424-862X",

publisher = "Cell Physiol Biochem Press GmbH \& Co KG",

number = "1-2",

}

TY - JOUR

T1 - Small interfering RNA specific for N-Methyl-D-aspartate receptor 2B offers neuroprotection to dopamine neurons through activation of MAP kinase

AU - Ng, Olivia T.W.

AU - Chen, L. W.

AU - Chan, Y. S.

AU - Yung, Ken K.L.

N1 - The present project was supported by Hong Kong Baptist University Research Committee Mini-Area of Excellence Scheme (RC/AOE/08-09/02) and General Research Fund, Hong Kong Research Grants Council (HKBU 262107 and HKBU 262210). The present work was also partially supported by the Area of Excellence Scheme established under the University Grants Committee of the HKSAR (Project No. AoE/B-15/01).

PY - 2013

Y1 - 2013

N2 - In the present study, N-methyl-D-aspartate receptor 2B (NR2B)-specific siRNA was applied in parkinsonian models. Our previous results showed that reduction in expression of N-methyl-D-aspartate receptor 1 (NR1), the key subunit of N-methyl-D-aspartate receptors, by antisense oligos amelio-rated the motor symptoms in the 6-hydroxydopamine (6-OHDA)-lesioned rat, an animal model of Parkinson's disease (PD).

AB - In the present study, N-methyl-D-aspartate receptor 2B (NR2B)-specific siRNA was applied in parkinsonian models. Our previous results showed that reduction in expression of N-methyl-D-aspartate receptor 1 (NR1), the key subunit of N-methyl-D-aspartate receptors, by antisense oligos amelio-rated the motor symptoms in the 6-hydroxydopamine (6-OHDA)-lesioned rat, an animal model of Parkinson's disease (PD).

KW - Extracellular signal-regulated kinase signaling pathway

KW - Motor symptom

KW - N-methyl-D-aspartate receptor 2B

KW - Parkinson's disease

KW - Small interference RNA

UR - https://www.scopus.com/pages/publications/84876141435

U2 - 10.1159/000334720

DO - 10.1159/000334720

M3 - Journal article

C2 - 22377595

AN - SCOPUS:84876141435

SN - 1424-862X

VL - 21

SP - 42

EP - 54

JO - NeuroSignals

JF - NeuroSignals

IS - 1-2

ER -

Small interfering RNA specific for N-Methyl-D-aspartate receptor 2B offers neuroprotection to dopamine neurons through activation of MAP kinase

Abstract

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