Small interfering RNA specific for N-Methyl-D-aspartate receptor 2B offers neuroprotection to dopamine neurons through activation of MAP kinase

Olivia T.W. Ng, L. W. Chen, Y. S. Chan, Kin Lam YUNG*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

4 Citations (Scopus)

Abstract

In the present study, N-methyl-D-aspartate receptor 2B (NR2B)-specific siRNA was applied in parkinsonian models. Our previous results showed that reduction in expression of N-methyl-D-aspartate receptor 1 (NR1), the key subunit of N-methyl-D-aspartate receptors, by antisense oligos amelio-rated the motor symptoms in the 6-hydroxydopamine (6-OHDA)-lesioned rat, an animal model of Parkinson's disease (PD).

Original languageEnglish
Pages (from-to)42-54
Number of pages13
JournalNeuroSignals
Volume21
Issue number1-2
DOIs
Publication statusPublished - 2013

Scopus Subject Areas

  • Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience

User-Defined Keywords

  • Extracellular signal-regulated kinase signaling pathway
  • Motor symptom
  • N-methyl-D-aspartate receptor 2B
  • Parkinson's disease
  • Small interference RNA

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