Size-dependent magnetomechanically enhanced photothermal antibacterial effect of Fe3O4@Au/PDA nanodurian

Yunqi Xu, Kang Wang, Yi Zhu*, Jing Wang, Dazheng Ci, Min Sang, Qunling Fang, Huaxia Deng, Xinglong Gong*, Ken Cham Fai Leung, Shouhu Xuan*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

Abstract

The global health crisis of bacterial resistance to antibiotics requires innovative antibacterial strategies. One promising solution is the exploitation of multifunctional nanoplatforms based on non-resistant antibacterial mechanisms. This work reports a novel Fe3O4@Au/polydopamine (PDA) nanodurian with excellent photothermal-magnetomechanic synergistic antibacterial effects. The one-step formed Au/PDA hybrid shell provides good photothermal properties and spiky surfaces for enhanced magnetomechanic effects. Upon near-infrared (NIR) irradiation, the Fe3O4@Au/PDA nanodurian (200 μg mL−1) achieved nearly 100% antibacterial effect against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). The efficiency of photothermal antimicrobial activity was further enhanced by the application of a rotating magnetic field (RMF), with the sterilization efficiency being increased by up to more than a half compared to the action alone. Interestingly, the size of the nanodurian has a significant impact on the synergistic sterilization effect, with larger particles showing a superior performance due to stronger chain-like structures in the magnetic field. Finally, the Fe3O4@Au/PDA nanodurian also demonstrates effective biofilm removal, with larger particles exhibiting the best eradication effect under the photothermal-magnetomechanic treatment. Overall, this magnetic field enhanced photothermal antibacterial strategy provides a promising broad-spectrum antimicrobial solution to combat bacterial infections. Thus, it possesses great potential in future nanomedicine and pollution treatment.

Original languageEnglish
Pages (from-to)17148-17162
Number of pages15
JournalDalton Transactions
Volume52
Issue number46
Early online date3 Nov 2023
DOIs
Publication statusPublished - 14 Dec 2023

Scopus Subject Areas

  • Inorganic Chemistry

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