Size-dependent electrophoretic migration and separation of water-soluble gold nanoclusters by capillary electrophoresis

Ting Wan, Fenglin Tang, Yanru Yin, Maoxue Zhang, Martin M F CHOI, Xiupei Yang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Recently, water-soluble gold nanoclusters (AuNCs) have attracted more and more attention due to their unique properties. In this study, penicillamine-protected gold nanoclusters (Pen-AuNCs) were synthesized and initially fractionated by sequential size-selective precipitation (SSSP). The crude Pen-AuNCs and SSSP fractions were separated by capillary zone electrophoresis (CZE) with a diode array detector. The effects of key parameters, including the concentration of phosphate buffer, pH value and the ethanol content were systematically investigated. The separation of water-soluble poly-disperse AuNCs were well achieved at 30 mM phosphate buffer with 7.5% EtOH, pH 12.0, and applied voltage of 15 kV. The linear correlation between AuNCs diameter and mobility was observed. This finding provides an important reference for CE separation and product purification of water-soluble AuNCs or other nanomaterials.

Original languageEnglish
Pages (from-to)1345-1352
Number of pages8
JournalElectrophoresis
Volume40
Issue number9
DOIs
Publication statusPublished - May 2019

Scopus Subject Areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry

User-Defined Keywords

  • Capillary electrophoresis
  • Electrophoretic mobility
  • Gold nanoclusters
  • Size separation

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