Site-specific binding of chelerythrine to single cytosine and thymine bulges in DNA hairpins.

Li Ping Bai*, Zhongzhen ZHAO, Zongwei CAI, Zhi Hong JIANG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Chelerythrine exhibits pronounced antitumor and apoptosis activities. In order to provide insights into the molecular mechanism of its pharmacological effects, binding selectivity of chelerythrine to a series of single-base bulged DNA hairpins has been assayed by using spectrofluorometric technique. The results indicated that chelerythrine binds specifically to C- and T-bulge sites in DNA hairpins, while sanguinarine exhibits extremely weak binding selectivity to any single-base bulged DNA hairpins, although it has very similar structure with chelerythrine.

Original languageEnglish
Pages (from-to)197-198
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number50
DOIs
Publication statusPublished - 2006

Scopus Subject Areas

  • Medicine(all)

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