Sinomenine ameliorates arthritis via MMPs, TIMPs, and cytokines in rats

Hua Zhou; Yuen Fan Wong; Jue Wang; Xiong Cai; Liang LIU

doi:10.1016/j.bbrc.2008.08.153

Sinomenine ameliorates arthritis via MMPs, TIMPs, and cytokines in rats

Hua Zhou, Yuen Fan Wong, Jue Wang, Xiong Cai, Liang LIU^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

103 Citations (Scopus)

Abstract

Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease that results in progressive joint destruction and substantial morbidity. The stem of the Chinese medicinal plant, Sinomenium acutum Rehder & Wilson (Family Menispermaceae), has been used to treat various rheumatic and arthritic diseases, of which the major bioactive component is sinomenine. We investigated the nature and molecular mechanisms of the anti-arthritic effect of sinomenine on collagen-induced arthritis in female Wistar rats. The results showed that sinomenine markedly suppressed the incidence and disease progression of established CIA, showing as dramatic reduction of paw swelling, ESR, and arthritic scores. Sinomenine suppressed the production of proinflammatory cytokines IL-1β and IL-6 in serum, inhibited the protein expressions and activities of MMP-2 and MMP-9, and elevated the protein expressions and activities of TIMP-1 and TIMP-3 in rat paw tissues.

Original language	English
Pages (from-to)	352-357
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	376
Issue number	2
DOIs	https://doi.org/10.1016/j.bbrc.2008.08.153
Publication status	Published - 14 Nov 2008

Scopus Subject Areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

User-Defined Keywords

Collagen-induced arthritis
Cytokines
MMPs
Sinomenine
TIMPs

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10.1016/j.bbrc.2008.08.153

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title = "Sinomenine ameliorates arthritis via MMPs, TIMPs, and cytokines in rats",

abstract = "Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease that results in progressive joint destruction and substantial morbidity. The stem of the Chinese medicinal plant, Sinomenium acutum Rehder & Wilson (Family Menispermaceae), has been used to treat various rheumatic and arthritic diseases, of which the major bioactive component is sinomenine. We investigated the nature and molecular mechanisms of the anti-arthritic effect of sinomenine on collagen-induced arthritis in female Wistar rats. The results showed that sinomenine markedly suppressed the incidence and disease progression of established CIA, showing as dramatic reduction of paw swelling, ESR, and arthritic scores. Sinomenine suppressed the production of proinflammatory cytokines IL-1β and IL-6 in serum, inhibited the protein expressions and activities of MMP-2 and MMP-9, and elevated the protein expressions and activities of TIMP-1 and TIMP-3 in rat paw tissues.",

keywords = "Collagen-induced arthritis, Cytokines, MMPs, Sinomenine, TIMPs",

author = "Hua Zhou and Wong, {Yuen Fan} and Jue Wang and Xiong Cai and Liang LIU",

note = "Funding Information: This research was funded by the Faculty Research Grant of Hong Kong Baptist University (FRG/05-06/II-73 and FRG/05-06/II-80). The authors wish to thank Dr. Martha Dahlen for checking English of this paper.",

year = "2008",

month = nov,

day = "14",

doi = "10.1016/j.bbrc.2008.08.153",

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T1 - Sinomenine ameliorates arthritis via MMPs, TIMPs, and cytokines in rats

AU - Zhou, Hua

AU - Wong, Yuen Fan

AU - Wang, Jue

AU - Cai, Xiong

AU - LIU, Liang

N1 - Funding Information: This research was funded by the Faculty Research Grant of Hong Kong Baptist University (FRG/05-06/II-73 and FRG/05-06/II-80). The authors wish to thank Dr. Martha Dahlen for checking English of this paper.

PY - 2008/11/14

Y1 - 2008/11/14

N2 - Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease that results in progressive joint destruction and substantial morbidity. The stem of the Chinese medicinal plant, Sinomenium acutum Rehder & Wilson (Family Menispermaceae), has been used to treat various rheumatic and arthritic diseases, of which the major bioactive component is sinomenine. We investigated the nature and molecular mechanisms of the anti-arthritic effect of sinomenine on collagen-induced arthritis in female Wistar rats. The results showed that sinomenine markedly suppressed the incidence and disease progression of established CIA, showing as dramatic reduction of paw swelling, ESR, and arthritic scores. Sinomenine suppressed the production of proinflammatory cytokines IL-1β and IL-6 in serum, inhibited the protein expressions and activities of MMP-2 and MMP-9, and elevated the protein expressions and activities of TIMP-1 and TIMP-3 in rat paw tissues.

AB - Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease that results in progressive joint destruction and substantial morbidity. The stem of the Chinese medicinal plant, Sinomenium acutum Rehder & Wilson (Family Menispermaceae), has been used to treat various rheumatic and arthritic diseases, of which the major bioactive component is sinomenine. We investigated the nature and molecular mechanisms of the anti-arthritic effect of sinomenine on collagen-induced arthritis in female Wistar rats. The results showed that sinomenine markedly suppressed the incidence and disease progression of established CIA, showing as dramatic reduction of paw swelling, ESR, and arthritic scores. Sinomenine suppressed the production of proinflammatory cytokines IL-1β and IL-6 in serum, inhibited the protein expressions and activities of MMP-2 and MMP-9, and elevated the protein expressions and activities of TIMP-1 and TIMP-3 in rat paw tissues.

KW - Collagen-induced arthritis

KW - Cytokines

KW - MMPs

KW - Sinomenine

KW - TIMPs

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DO - 10.1016/j.bbrc.2008.08.153

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AN - SCOPUS:52949088275

SN - 0006-291X

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JF - Biochemical and Biophysical Research Communications

IS - 2

ER -

Sinomenine ameliorates arthritis via MMPs, TIMPs, and cytokines in rats

Abstract

Scopus Subject Areas

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