Single-cell analysis of p53 transitional dynamics unravels stimulus- and cell type-dependent signaling output motifs

Keyphrases

• P53 Pathway 100%
• Transitional Dynamics 100%
• Single-cell Analysis 100%
• Network Motifs 66%
• Mathematical Modeling 66%
• Cancer Cells 66%
• Network Topology 66%
• Negative Feedback 66%
• Dynamic Response 66%
• Signaling Network 66%
• P53 Dynamics 66%
• Mechanistic Understanding 66%
• Dynamic Output 66%
• Mechanism of Action 33%
• External Stimuli 33%
• Dose Effect 33%
• Mammalian Cells 33%
• Positive Feedback 33%
• P53 Network 33%
• Network Dynamics 33%
• Drug Response 33%
• Biological Systems 33%
• In Cancer 33%
• Drug Sensitivity 33%
• Anticancer Drugs 33%
• 5-fluorouracil (5-FU) 33%
• Signaling Molecules 33%
• Type-specific 33%
• Phenotypic Variation 33%
• Functional Role 33%
• Signal Response 33%
• Drug Action 33%
• Single-cell Imaging 33%
• Distinct Mechanism 33%
• Imaging Model 33%
• Topological Methods 33%
• Phenotypic Heterogeneity 33%
• Drug Concentration 33%
• Stress Stimuli 33%
• Conflicting Evidence 33%
• Etoposide 33%
• Nutlin-3 33%
• Differential Dynamics 33%
• Network Activity 33%
• Functional Change 33%
• Stimulus Level 33%
• Generic Network 33%
• Complex Biological Networks 33%
• Systemic Network 33%
• Action Variation 33%
• MDM2-p53 Interaction 33%

Biochemistry, Genetics and Molecular Biology

• Dynamics 100%
• P53 100%
• Single-Cell Analysis 100%
• Cancer Cell 20%
• Mediator 20%
• Network Motif 20%
• Drug Response 10%
• Anticancer 10%
• Drug Sensitivity 10%
• Signaling Protein 10%
• Phenotypic Variation 10%
• Cellular Imaging 10%
• Drug Mechanism 10%
• Mdm2 10%
• Fluorouracil 10%
• Phenotypic Heterogeneity 10%
• Drug Concentration 10%
• Positive Feedback 10%
• Product Inhibition 10%
• Nutlin 10%