TY - JOUR
T1 - Simiao Decoction alleviates hyperuricemia-induced renal injury through regulating gut dysbiosis and decreasing gut-derived uremic toxins
AU - Zhou, Xinghong
AU - Liu, Xiaoyu
AU - Peng, Baizhao
AU - Yang, Ying
AU - Lu, Hanqi
AU - Li, Dexian
AU - Deng, Yijian
AU - Jiang, Zihao
AU - Wu, Chuanghai
AU - Fang, Wen
AU - You, Yanting
AU - Kwan, Hiu Yee
AU - Zhao, Xiaoshan
AU - Liu, Yanyan
N1 - This work was supported by the Joint Funds of National Natural Science Foundation of China [grant number U22A20365], National Natural Science Foundation of China [grant number 82274499, T2341019, 82405279], the Key Project of National Natural Science Foundation of China [grant number 81830117], the Guangzhou Science and Technology Plan Project [grant number 2024B03J1343], the Major scientific and technological project of Guangzhou Municipal Health Commission [grant number 20252D003], Guangdong Basic and Applied Basic Research Foundation, China [grant number 2023A1515110757], Dongguan social development technology program (High level hospital constructon project), China [grant number 20231800913372].
Publisher Copyright:
© The Author(s) 2026
https://www.nature.com/articles/s41522-026-00923-x_reference.pdf
PY - 2026/1/31
Y1 - 2026/1/31
N2 - Renal injury is a common complication of hyperuricemia (HUA), which has been recognized as an independent risk factor for chronic kidney disease (CKD). The gut-kidney axis theory suggests that targeting the gut microbiota may be a potential treatment option for kidney disease. In this study, we utilized a spontaneous HUA rat model to demonstrate that Simiao decoction (SMD), a traditional Chinese medicine formula, can effectively alleviate HUA-induced renal injury by modulating gut microbiota and bacterial metabolism of tryptophan and tyrosine, thereby reducing gut-derived uremic toxins such as indoxyl sulfate (IS) and p-Cresol (PC). Fecal microbiota transplantation (FMT) further confirmed that the therapeutic effect of SMD was mediated by gut microbiota. Finally, in vitro studies revealed that IS promotes epithelial-mesenchymal transition (EMT) while PC induces cellular senescence in tubular cells. Collectively, our findings suggest that SMD can effectively alleviate HUA-induced renal injury through regulating gut dysbiosis and decreasing gut-derived uremic toxins. This study sheds light on a novel mechanism by which SMD exerts its effects on HUA-induced renal injury. (Figure presented.)
AB - Renal injury is a common complication of hyperuricemia (HUA), which has been recognized as an independent risk factor for chronic kidney disease (CKD). The gut-kidney axis theory suggests that targeting the gut microbiota may be a potential treatment option for kidney disease. In this study, we utilized a spontaneous HUA rat model to demonstrate that Simiao decoction (SMD), a traditional Chinese medicine formula, can effectively alleviate HUA-induced renal injury by modulating gut microbiota and bacterial metabolism of tryptophan and tyrosine, thereby reducing gut-derived uremic toxins such as indoxyl sulfate (IS) and p-Cresol (PC). Fecal microbiota transplantation (FMT) further confirmed that the therapeutic effect of SMD was mediated by gut microbiota. Finally, in vitro studies revealed that IS promotes epithelial-mesenchymal transition (EMT) while PC induces cellular senescence in tubular cells. Collectively, our findings suggest that SMD can effectively alleviate HUA-induced renal injury through regulating gut dysbiosis and decreasing gut-derived uremic toxins. This study sheds light on a novel mechanism by which SMD exerts its effects on HUA-induced renal injury. (Figure presented.)
UR - https://www.scopus.com/pages/publications/105032232993
U2 - 10.1038/s41522-026-00923-x
DO - 10.1038/s41522-026-00923-x
M3 - Journal article
SN - 2055-5008
VL - 12
JO - npj Biofilms and Microbiomes
JF - npj Biofilms and Microbiomes
IS - 1
M1 - 58
ER -