Signaling pathways regulating blood–tissue barriers — Lesson from the testis

Qing Wen, Elizabeth I. Tang, Ying Gao, Tito T. Jesus, Darren S. Chu, Will M. Lee, Chris K C WONG, Yi Xun Liu, Xiang Xiao, Bruno Silvestrini, C. Yan Cheng*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

34 Citations (Scopus)


Signaling pathways that regulate blood–tissue barriers are important for studying the biology of various blood–tissue barriers. This information, if deciphered and better understood, will provide better therapeutic management of diseases particularly in organs that are sealed by the corresponding blood–tissue barriers from systemic circulation, such as the brain and the testis. These barriers block the access of antibiotics and/or chemotherapeutical agents across the corresponding barriers. Studies in the last decade using the blood–testis barrier (BTB) in rats have demonstrated the presence of several signaling pathways that are crucial to modulate BTB function. Herein, we critically evaluate these findings and provide hypothetical models regarding the underlying mechanisms by which these signaling molecules/pathways modulate BTB dynamics. This information should be carefully evaluated to examine their applicability in other tissue barriers which shall benefit future functional studies in the field. This article is part of a Special Issue entitled: Gap Junction Proteins edited by Jean Claude Herve.

Original languageEnglish
Pages (from-to)141-153
Number of pages13
JournalBiochimica et Biophysica Acta - Biomembranes
Issue number1
Publication statusPublished - Jan 2018

Scopus Subject Areas

  • Biophysics
  • Biochemistry
  • Cell Biology

User-Defined Keywords

  • Blood–testis barrier
  • Blood–tissue barriers
  • Cytoskeleton
  • F-actin
  • Germ cell
  • Microtubules
  • Motor proteins
  • mTOR
  • mTORC1
  • mTORC2
  • Nucleation proteins
  • Seminiferous epithelial cycle
  • Sertoli cell
  • Spermatogenesis
  • Testis


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