Shape analysis of somatosensory evoked potentials to detect a focal spinal cord lesion

G. Agrawal; D. L. Sherman; P. Walczak; J. W.M. Bulte; N. V. Thakor; D. A. Kerr; A. H. All

doi:10.1109/NEBC.2009.4967710

Shape analysis of somatosensory evoked potentials to detect a focal spinal cord lesion

G. Agrawal^*
, D. L. Sherman
, P. Walczak
, J. W.M. Bulte
, N. V. Thakor
, D. A. Kerr
, A. H. All

^*Corresponding author for this work

Department of Chemistry

Research output: Chapter in book/report/conference proceeding › Conference proceeding › peer-review

7 Citations (Scopus)

Abstract

In this paper, the shape of the Somatosensory Evoked Potential (SEP) signals is analyzed to detect a focal lesion in the spinal cord of rats. SEPs can be used to reliably assess the spinal cord integrity. However traditional time-domain analysis often needs human intervention because of common difficulty in SEP peak detection due to low signal-to-noise ratio or flattening of SEPs during injury. We have proposed a novel shape analysis technique for SEPs, in which we obtain the slope information for the entire waveform in specific time bins. This technique does not involve any peak detection, and can be used without human intervention. We studied the effectiveness of this technique in a focal Experimental Autoimmune Encephalomyelitis model, in which a focal demyelinating lesion is induced in the spinal cord by injecting cytokine-ethidium bromide into dorsal white matter at T8 after immunization using Myelin Oligodendrocyte Glycoprotein combined with incomplete Freund's adjuvant. The technique was applied to SEPs recorded before and after lesion from 12 rats. The results showed the effect of injury to the SEPs from hindlimbs, hence demonstrating great potential of this technique to detect an injury to the spinal cord.

Original language	English
Title of host publication	NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference
Publisher	IEEE
ISBN (Print)	9781424443628
DOIs	https://doi.org/10.1109/NEBC.2009.4967710
Publication status	Published - 3 Apr 2009
Event	IEEE 35th Annual Northeast Bioengineering Conference, NEBEC 2009 - Boston, MA, United States Duration: 3 Apr 2009 → 5 Apr 2009

Publication series

Name	Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
ISSN (Print)	1071-121X

Conference

Conference	IEEE 35th Annual Northeast Bioengineering Conference, NEBEC 2009
Country/Territory	United States
City	Boston, MA
Period	3/04/09 → 5/04/09

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10.1109/NEBC.2009.4967710

Cite this

Agrawal, G., Sherman, D. L., Walczak, P., Bulte, J. W. M., Thakor, N. V., Kerr, D. A., & All, A. H. (2009). Shape analysis of somatosensory evoked potentials to detect a focal spinal cord lesion. In NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference Article 4967710 (Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC). IEEE. https://doi.org/10.1109/NEBC.2009.4967710

@inproceedings{2cdbd6f4a30f4ea8a7f59615372dadc2,

title = "Shape analysis of somatosensory evoked potentials to detect a focal spinal cord lesion",

abstract = "In this paper, the shape of the Somatosensory Evoked Potential (SEP) signals is analyzed to detect a focal lesion in the spinal cord of rats. SEPs can be used to reliably assess the spinal cord integrity. However traditional time-domain analysis often needs human intervention because of common difficulty in SEP peak detection due to low signal-to-noise ratio or flattening of SEPs during injury. We have proposed a novel shape analysis technique for SEPs, in which we obtain the slope information for the entire waveform in specific time bins. This technique does not involve any peak detection, and can be used without human intervention. We studied the effectiveness of this technique in a focal Experimental Autoimmune Encephalomyelitis model, in which a focal demyelinating lesion is induced in the spinal cord by injecting cytokine-ethidium bromide into dorsal white matter at T8 after immunization using Myelin Oligodendrocyte Glycoprotein combined with incomplete Freund's adjuvant. The technique was applied to SEPs recorded before and after lesion from 12 rats. The results showed the effect of injury to the SEPs from hindlimbs, hence demonstrating great potential of this technique to detect an injury to the spinal cord.",

author = "G. Agrawal and Sherman, \{D. L.\} and P. Walczak and Bulte, \{J. W.M.\} and Thakor, \{N. V.\} and Kerr, \{D. A.\} and All, \{A. H.\}",

note = "Publisher Copyright: {\textcopyright} 2009, IEEE.; IEEE 35th Annual Northeast Bioengineering Conference, NEBEC 2009 ; Conference date: 03-04-2009 Through 05-04-2009",

year = "2009",

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doi = "10.1109/NEBC.2009.4967710",

language = "English",

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Agrawal, G, Sherman, DL, Walczak, P, Bulte, JWM, Thakor, NV, Kerr, DA & All, AH 2009, Shape analysis of somatosensory evoked potentials to detect a focal spinal cord lesion. in NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference., 4967710, Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC, IEEE, IEEE 35th Annual Northeast Bioengineering Conference, NEBEC 2009, Boston, MA, United States, 3/04/09. https://doi.org/10.1109/NEBC.2009.4967710

Shape analysis of somatosensory evoked potentials to detect a focal spinal cord lesion. / Agrawal, G.; Sherman, D. L.; Walczak, P. et al.
NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference. IEEE, 2009. 4967710 (Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC).

Research output: Chapter in book/report/conference proceeding › Conference proceeding › peer-review

TY - GEN

T1 - Shape analysis of somatosensory evoked potentials to detect a focal spinal cord lesion

AU - Agrawal, G.

AU - Sherman, D. L.

AU - Walczak, P.

AU - Bulte, J. W.M.

AU - Thakor, N. V.

AU - Kerr, D. A.

AU - All, A. H.

PY - 2009/4/3

Y1 - 2009/4/3

N2 - In this paper, the shape of the Somatosensory Evoked Potential (SEP) signals is analyzed to detect a focal lesion in the spinal cord of rats. SEPs can be used to reliably assess the spinal cord integrity. However traditional time-domain analysis often needs human intervention because of common difficulty in SEP peak detection due to low signal-to-noise ratio or flattening of SEPs during injury. We have proposed a novel shape analysis technique for SEPs, in which we obtain the slope information for the entire waveform in specific time bins. This technique does not involve any peak detection, and can be used without human intervention. We studied the effectiveness of this technique in a focal Experimental Autoimmune Encephalomyelitis model, in which a focal demyelinating lesion is induced in the spinal cord by injecting cytokine-ethidium bromide into dorsal white matter at T8 after immunization using Myelin Oligodendrocyte Glycoprotein combined with incomplete Freund's adjuvant. The technique was applied to SEPs recorded before and after lesion from 12 rats. The results showed the effect of injury to the SEPs from hindlimbs, hence demonstrating great potential of this technique to detect an injury to the spinal cord.

AB - In this paper, the shape of the Somatosensory Evoked Potential (SEP) signals is analyzed to detect a focal lesion in the spinal cord of rats. SEPs can be used to reliably assess the spinal cord integrity. However traditional time-domain analysis often needs human intervention because of common difficulty in SEP peak detection due to low signal-to-noise ratio or flattening of SEPs during injury. We have proposed a novel shape analysis technique for SEPs, in which we obtain the slope information for the entire waveform in specific time bins. This technique does not involve any peak detection, and can be used without human intervention. We studied the effectiveness of this technique in a focal Experimental Autoimmune Encephalomyelitis model, in which a focal demyelinating lesion is induced in the spinal cord by injecting cytokine-ethidium bromide into dorsal white matter at T8 after immunization using Myelin Oligodendrocyte Glycoprotein combined with incomplete Freund's adjuvant. The technique was applied to SEPs recorded before and after lesion from 12 rats. The results showed the effect of injury to the SEPs from hindlimbs, hence demonstrating great potential of this technique to detect an injury to the spinal cord.

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BT - NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference

PB - IEEE

T2 - IEEE 35th Annual Northeast Bioengineering Conference, NEBEC 2009

Y2 - 3 April 2009 through 5 April 2009

ER -

Agrawal G, Sherman DL, Walczak P, Bulte JWM, Thakor NV, Kerr DA et al. Shape analysis of somatosensory evoked potentials to detect a focal spinal cord lesion. In NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference. IEEE. 2009. 4967710. (Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC). doi: 10.1109/NEBC.2009.4967710

Shape analysis of somatosensory evoked potentials to detect a focal spinal cord lesion

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