Sex differences in release of cardiac troponin T after endurance exercise

Zhaowei Kong, Jinlei Nie*, Hua Lin, Keith George, Gang Zhao, Haifeng Zhang, Tom K K TONG, Qingde Shi

*Corresponding author for this work

    Research output: Contribution to journalJournal articlepeer-review

    29 Citations (Scopus)


    Context: Post-exercise cardiac troponin release has been extensively described in athletic groups but little attention has been given to any role of sex in mediating this phenomenon. Objective: We compared the release of cardiac troponin T (cTnT) after endurance running in training-experience, biological-age and maturity-matched young male and female runners. Materials and methods: Nineteen male (training history: 2.3 ± 1.0 years; mean age: 16.1 ± 1.2 years; Tanner stage: 3.7 ± 0.6) and 19 female (training history: 2.2 ± 1.0 years; mean age: 15.9 ± 1.4 years; Tanner stage: 4.0 ± 0.4) runners performed a 21 km run with “all-out” effort. Serum cTnT levels were assessed at pre-exercise (Pre-ex) and at 4 h post-exercise (Post-ex). Results: At Pre-ex, cTnT concentrations were below the 99th percentile value (10 ng.l−1) in 32/38 runners. Post-ex cTnT increased in all subjects but the response was substantially higher (p < 0.05) in males [median (range): 210 (20–1360) ng.l−1] than females [median (range): 80 (10–550) ng.l−1]. At Post-ex, 95% (95% confidence interval: 75–99%) of males and 63% (95% confidence interval: 41–81%) of females (p < 0.05) had cTnT concentrations above the cut-off for acute myocardial infarction. Conclusions: The present data suggest that post-exercise cTnT elevation occurs in all runners but is augmented in young male compared to female athletes.

    Original languageEnglish
    Pages (from-to)345-350
    Number of pages6
    Issue number3-4
    Publication statusPublished - 19 May 2017

    Scopus Subject Areas

    • Biochemistry
    • Clinical Biochemistry
    • Health, Toxicology and Mutagenesis

    User-Defined Keywords

    • adolescents
    • Cardiac biomarker
    • endurance exercise
    • sex


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