Serum amyloid A1 polymorphisms as risk factors in oesophageal squamous cell carcinoma

Hong Lok Lung; M. L. Lung; S. Law

Serum amyloid A1 polymorphisms as risk factors in oesophageal squamous cell carcinoma

Hong Lok Lung^*, M. L. Lung, S. Law

^*Corresponding author for this work

Department of Biology

Research output: Contribution to journal › Journal article › peer-review

Abstract

1. Serum amyloid A1 provides 100% sensitivity and 100% specificity for early detection of oesophageal squamous cell carcinoma. The choice of using serum or plasma samples is critical for circulating serum amyloid A detection.
2. The median survival time of patients with serum amyloid A1.3/1.5 genotype was shorter than that of patients with other genotypes (10.63 months vs 20.41 months, P=0.004). This was likely due to the extra high-circulating interleukin 6 concentrations.

Original language	English
Pages (from-to)	S4-S8
Number of pages	5
Journal	Hong Kong Medical Journal
Volume	25
Issue number	5, Suppl 7
Publication status	Published - Oct 2019

Scopus Subject Areas

General Medicine

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Cite this

@article{61fc9176159e4fd29bd3cab637fe0f0c,

title = "Serum amyloid A1 polymorphisms as risk factors in oesophageal squamous cell carcinoma",

abstract = "1. Serum amyloid A1 provides 100% sensitivity and 100% specificity for early detection of oesophageal squamous cell carcinoma. The choice of using serum or plasma samples is critical for circulating serum amyloid A detection.2. The median survival time of patients with serum amyloid A1.3/1.5 genotype was shorter than that of patients with other genotypes (10.63 months vs 20.41 months, P=0.004). This was likely due to the extra high-circulating interleukin 6 concentrations.",

author = "Lung, {Hong Lok} and Lung, {M. L.} and S. Law",

note = "This study was supported by the Health and Medical Research Fund, Food and Health Bureau, Hong Kong SAR Government (#01120886). We thank the Hong Kong Red Cross for providing blood samples from healthy individuals. We also thank Dr Didier Trono for the supply of the lentiviral vectors, pWPI, pMD2.G, and psPAX2.",

year = "2019",

month = oct,

language = "English",

volume = "25",

pages = "S4--S8",

journal = "Hong Kong Medical Journal",

issn = "1024-2708",

publisher = "Hong Kong Academy of Medicine Press",

number = "5, Suppl 7",

}

TY - JOUR

T1 - Serum amyloid A1 polymorphisms as risk factors in oesophageal squamous cell carcinoma

AU - Lung, Hong Lok

AU - Lung, M. L.

AU - Law, S.

N1 - This study was supported by the Health and Medical Research Fund, Food and Health Bureau, Hong Kong SAR Government (#01120886). We thank the Hong Kong Red Cross for providing blood samples from healthy individuals. We also thank Dr Didier Trono for the supply of the lentiviral vectors, pWPI, pMD2.G, and psPAX2.

PY - 2019/10

Y1 - 2019/10

N2 - 1. Serum amyloid A1 provides 100% sensitivity and 100% specificity for early detection of oesophageal squamous cell carcinoma. The choice of using serum or plasma samples is critical for circulating serum amyloid A detection.2. The median survival time of patients with serum amyloid A1.3/1.5 genotype was shorter than that of patients with other genotypes (10.63 months vs 20.41 months, P=0.004). This was likely due to the extra high-circulating interleukin 6 concentrations.

AB - 1. Serum amyloid A1 provides 100% sensitivity and 100% specificity for early detection of oesophageal squamous cell carcinoma. The choice of using serum or plasma samples is critical for circulating serum amyloid A detection.2. The median survival time of patients with serum amyloid A1.3/1.5 genotype was shorter than that of patients with other genotypes (10.63 months vs 20.41 months, P=0.004). This was likely due to the extra high-circulating interleukin 6 concentrations.

UR - https://www.hkmj.org/abstracts/v25%20Suppl%207n5/4.htm

UR - http://www.scopus.com/inward/record.url?scp=85075522663&partnerID=8YFLogxK

M3 - Journal article

C2 - 31761762

AN - SCOPUS:85075522663

SN - 1024-2708

VL - 25

SP - S4-S8

JO - Hong Kong Medical Journal

JF - Hong Kong Medical Journal

IS - 5, Suppl 7

ER -

Serum amyloid A1 polymorphisms as risk factors in oesophageal squamous cell carcinoma

Abstract

Scopus Subject Areas

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