Separation of ephedrine alkaloids and non-ephedrine alkaloids in Ephedra sinica and study on thrombolysis effect of non-ephedrine alkaloids

Zi Jiao Li*, Yi Yang, Ming Yu Ding, Zhongzhen ZHAO, De Lin Liu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: To separate the total extract of Ephedra sinica Stapf into two parts, ephedrine alkaloids and non-ephedrine alkaloids, and to investigate if the non-ephedrine alkaloids part has thrombolysis effect. METHODS: Chloroform was used to isolate ephedrine alkaloids and non-ephedrine alkaloids. A cerebral ischemic model of SD mice developed by ferric chloride was applied to test the thrombolysis effect of non-ephedrine alkaloids part. RESULTS: The non-ephedrine alkaloids part had apparent thrombolysis effect. CONCLUSION: There may be some effective components in non-ephedrine alkaloids part which has shown the total pharmacological effect of Ephedra sinica Stapf.

Original languageEnglish
Pages (from-to)423-425
Number of pages3
JournalChinese Pharmaceutical Journal
Volume39
Issue number6
Publication statusPublished - Jun 2004

Scopus Subject Areas

  • Pharmacology
  • Pharmaceutical Science

User-Defined Keywords

  • Cerebral ischemic model
  • Ephedra sinica Stapf
  • Non-ephedrine alkaloids
  • Thrombolysis

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