Sensitization of Hep3B hepatoma cells to cisplatin and doxorubicin by corilagin

Roberto Gambari; Desmond Kwok Po Hau; Wai Yeung Wong; Chung Hin Chui

doi:10.1002/ptr.5049

Sensitization of Hep3B hepatoma cells to cisplatin and doxorubicin by corilagin

Roberto Gambari
, Desmond Kwok Po Hau
, Wai Yeung Wong
, Chung Hin Chui^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

27 Citations (Scopus)

Abstract

The anticancer action of gallotannins is a well-developed topic. We have demonstrated the in vivo antitumour activity of corilagin on Hep3B hepatoma using the xenograft athymic nude mice model. Here, we further report the potential sensitization of Hep3B hepatoma cells to cisplatin and doxorubicin by corilagin. Our results showed that corilagin is able to enhance the cytotoxicity of both cisplatin and doxorubicin on the Hep3B hepatoma cells. We speculate the possible use of corilagin in combination with low dosages of the anticancer chemotherapeutic standard drugs like cisplatin and doxorubicin, with the aim of obtaining an increment in the anticancer effect.

Original language	English
Pages (from-to)	781-783
Number of pages	3
Journal	Phytotherapy Research
Volume	28
Issue number	5
DOIs	https://doi.org/10.1002/ptr.5049
Publication status	Published - May 2014

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

User-Defined Keywords

cisplatin
corilagin
doxorubicin
Hep3B hepatoma cells

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10.1002/ptr.5049

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title = "Sensitization of Hep3B hepatoma cells to cisplatin and doxorubicin by corilagin",

abstract = "The anticancer action of gallotannins is a well-developed topic. We have demonstrated the in vivo antitumour activity of corilagin on Hep3B hepatoma using the xenograft athymic nude mice model. Here, we further report the potential sensitization of Hep3B hepatoma cells to cisplatin and doxorubicin by corilagin. Our results showed that corilagin is able to enhance the cytotoxicity of both cisplatin and doxorubicin on the Hep3B hepatoma cells. We speculate the possible use of corilagin in combination with low dosages of the anticancer chemotherapeutic standard drugs like cisplatin and doxorubicin, with the aim of obtaining an increment in the anticancer effect.",

keywords = "cisplatin, corilagin, doxorubicin, Hep3B hepatoma cells",

author = "Roberto Gambari and Hau, \{Desmond Kwok Po\} and Wong, \{Wai Yeung\} and Chui, \{Chung Hin\}",

note = "This work was supported by the starting fund from RO (38-40-116) of HKBU to Dr. C.H. Chui and a research fund between Innovative Technology Commission and Research Grant Committee (From Professor KY Wong, Hong Kong Polytechnic University).",

year = "2014",

month = may,

doi = "10.1002/ptr.5049",

language = "English",

volume = "28",

pages = "781--783",

journal = "Phytotherapy Research",

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TY - JOUR

T1 - Sensitization of Hep3B hepatoma cells to cisplatin and doxorubicin by corilagin

AU - Gambari, Roberto

AU - Hau, Desmond Kwok Po

AU - Wong, Wai Yeung

AU - Chui, Chung Hin

N1 - This work was supported by the starting fund from RO (38-40-116) of HKBU to Dr. C.H. Chui and a research fund between Innovative Technology Commission and Research Grant Committee (From Professor KY Wong, Hong Kong Polytechnic University).

PY - 2014/5

Y1 - 2014/5

N2 - The anticancer action of gallotannins is a well-developed topic. We have demonstrated the in vivo antitumour activity of corilagin on Hep3B hepatoma using the xenograft athymic nude mice model. Here, we further report the potential sensitization of Hep3B hepatoma cells to cisplatin and doxorubicin by corilagin. Our results showed that corilagin is able to enhance the cytotoxicity of both cisplatin and doxorubicin on the Hep3B hepatoma cells. We speculate the possible use of corilagin in combination with low dosages of the anticancer chemotherapeutic standard drugs like cisplatin and doxorubicin, with the aim of obtaining an increment in the anticancer effect.

AB - The anticancer action of gallotannins is a well-developed topic. We have demonstrated the in vivo antitumour activity of corilagin on Hep3B hepatoma using the xenograft athymic nude mice model. Here, we further report the potential sensitization of Hep3B hepatoma cells to cisplatin and doxorubicin by corilagin. Our results showed that corilagin is able to enhance the cytotoxicity of both cisplatin and doxorubicin on the Hep3B hepatoma cells. We speculate the possible use of corilagin in combination with low dosages of the anticancer chemotherapeutic standard drugs like cisplatin and doxorubicin, with the aim of obtaining an increment in the anticancer effect.

KW - cisplatin

KW - corilagin

KW - doxorubicin

KW - Hep3B hepatoma cells

UR - https://www.scopus.com/pages/publications/84899484022

U2 - 10.1002/ptr.5049

DO - 10.1002/ptr.5049

M3 - Journal article

C2 - 23913631

AN - SCOPUS:84899484022

SN - 0951-418X

VL - 28

SP - 781

EP - 783

JO - Phytotherapy Research

JF - Phytotherapy Research

IS - 5

ER -

Sensitization of Hep3B hepatoma cells to cisplatin and doxorubicin by corilagin

Abstract

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