TY - JOUR
T1 - Sensitive and responsive upconversion nanoprobes for fluorescence turn-on detection of glucose concentration
AU - Zha, Shuai
AU - Li, Haolan
AU - Law, Ga Lai
AU - Wong, Ka Leung
AU - All, Angelo H.
N1 - Funding Information:
This study was supported by the Hong Kong Baptist University: Start-Up Tier 1 Fund # 21.4531.162640 (PI: A. H. A.), Faculty Seed Fund # 31.4531.179234 (PI: A. H. A.), Initiation Grant for Faculty Niche Research Areas (IG-FNRA) 2020/21 (PI: A. H. A.), Research Grant Council General Research Fund (GRF) 2021-22 (PI: A. H. A.), and NSFC/RGC Joint Research Scheme 2021/2022 N_HKBU209/21(PI: K.-L. W.).
Publisher Copyright:
© 2023 The Author(s).
PY - 2023/3
Y1 - 2023/3
N2 - Various approaches for detecting glucose concentration in real time are emerging at a breakneck pace. Glucose metabolism is closely linked to severe pathological events, which would either cause or predispose many progressive diseases in human. Herein, hydrophilic upconversion nanoprobes NaGdF4: Yb3+, Er3+@Ag anchored with glucose oxidase (GOx) for glucose detection with lower detection limits have been efficaciously constructed. In the upconversion nanoprobes, NaGdF4: Yb3+, Er3+ cores, and Ag layers act as energy donors and effective quenchers, respectively, through energy transfer. Moreover, the layer of Ag may disintegrate by H2O2 in the presence of glucose when glucose oxidase anchoring on the exterior of NaGdF4: Yb3+, Er3+@Ag nanoprobes, which leads to the phenomenon of upconverting emission recovery. Additionally, NaGdF4: Yb3+, Er3+@Ag-GOx has an ultralow detection limit of 1.77 μmol L−1 on glucose detection, and it can achieve optical bioimaging to distinguish cancer cells from normal cells. As a result, the NaGdF4: Yb3+, Er3+@Ag nanoprobes could be expanded to detect diverse H2O2-involved analytes. Overall, this nanoprobe has promising potential to be a compelling tool for the biomedical applications.
AB - Various approaches for detecting glucose concentration in real time are emerging at a breakneck pace. Glucose metabolism is closely linked to severe pathological events, which would either cause or predispose many progressive diseases in human. Herein, hydrophilic upconversion nanoprobes NaGdF4: Yb3+, Er3+@Ag anchored with glucose oxidase (GOx) for glucose detection with lower detection limits have been efficaciously constructed. In the upconversion nanoprobes, NaGdF4: Yb3+, Er3+ cores, and Ag layers act as energy donors and effective quenchers, respectively, through energy transfer. Moreover, the layer of Ag may disintegrate by H2O2 in the presence of glucose when glucose oxidase anchoring on the exterior of NaGdF4: Yb3+, Er3+@Ag nanoprobes, which leads to the phenomenon of upconverting emission recovery. Additionally, NaGdF4: Yb3+, Er3+@Ag-GOx has an ultralow detection limit of 1.77 μmol L−1 on glucose detection, and it can achieve optical bioimaging to distinguish cancer cells from normal cells. As a result, the NaGdF4: Yb3+, Er3+@Ag nanoprobes could be expanded to detect diverse H2O2-involved analytes. Overall, this nanoprobe has promising potential to be a compelling tool for the biomedical applications.
KW - Glucose detection
KW - Lanthanide-doped upconversion nanoparticles
KW - Optical bioimaging
KW - Surface modification
KW - Upconversion emission recovery
UR - http://www.scopus.com/inward/record.url?scp=85149334597&partnerID=8YFLogxK
U2 - 10.1016/j.matdes.2023.111800
DO - 10.1016/j.matdes.2023.111800
M3 - Journal article
AN - SCOPUS:85149334597
SN - 0264-1275
VL - 227
JO - Materials and Design
JF - Materials and Design
M1 - 111800
ER -
