Sensitive and responsive pentiptycene-based molecular fluorescence chemosensor for detection of polyamines

Junrong Huang; Weijian Ye; Shuai Zha; Yezi Tao; Min Yang; Ke Huang; Jiqiang Liu; Yan Ho Fung; Yang Li; Penghao Li; Lizhi Zhu; Chi Sing Lee

doi:10.1016/j.jlumin.2020.117856

Sensitive and responsive pentiptycene-based molecular fluorescence chemosensor for detection of polyamines

Junrong Huang
, Weijian Ye
, Shuai Zha
, Yezi Tao
, Min Yang
, Ke Huang
, Jiqiang Liu
, Yan Ho Fung
, Yang Li
, Penghao Li
, Lizhi Zhu^*
, Chi Sing Lee^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

14 Citations (Scopus)

Abstract

A rapid and convenient detection method for biogenic polyamines is of great importance for early diagnosis of many diseases. In this work, a tetraphenyl ethylene (TPE) conjugated pentiptycene has been synthesized and showed to be a highly responsive fluorescent sensor toward polyamines. The detection limit of this probe is in the sub-micromolar level, and it also shows good selectivity for spermine. This small organic molecular bio-indicator can be used to detect spermine in artificial urine, demonstrating the potential application in clinical practice.

Original language	English
Article number	117856
Journal	Journal of Luminescence
Volume	232
Early online date	17 Dec 2020
DOIs	https://doi.org/10.1016/j.jlumin.2020.117856
Publication status	Published - Apr 2021

User-Defined Keywords

Chemosensor
Pentiptycene
Responsive luminescence
Spermine
Tetraphenyl ethylene

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10.1016/j.jlumin.2020.117856

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@article{e986fcd1c4d24de88cd8fa12ced072e0,

title = "Sensitive and responsive pentiptycene-based molecular fluorescence chemosensor for detection of polyamines",

abstract = "A rapid and convenient detection method for biogenic polyamines is of great importance for early diagnosis of many diseases. In this work, a tetraphenyl ethylene (TPE) conjugated pentiptycene has been synthesized and showed to be a highly responsive fluorescent sensor toward polyamines. The detection limit of this probe is in the sub-micromolar level, and it also shows good selectivity for spermine. This small organic molecular bio-indicator can be used to detect spermine in artificial urine, demonstrating the potential application in clinical practice.",

keywords = "Chemosensor, Pentiptycene, Responsive luminescence, Spermine, Tetraphenyl ethylene",

author = "Junrong Huang and Weijian Ye and Shuai Zha and Yezi Tao and Min Yang and Ke Huang and Jiqiang Liu and Fung, \{Yan Ho\} and Yang Li and Penghao Li and Lizhi Zhu and Lee, \{Chi Sing\}",

note = "Funding Information: This work was supported by the Shenzhen Science, Technology and Innovation Committee ( JCYJ20150626111042525 and JCYJ20160330095659560 ), Shenzhen Key Medical Discipline Construction Fund (No. SZXK060 ), Chinese Postdoctoral Science Foundation ( 2019M663109 ), Hong Kong Baptist University ( RC-SGT2/18–19/SCI/005 and RC-ICRS-18-19-01A ), Peking University Shenzhen Graduate School andShenzhen Second People's Hospital . ",

year = "2021",

month = apr,

doi = "10.1016/j.jlumin.2020.117856",

language = "English",

volume = "232",

journal = "Journal of Luminescence",

issn = "0022-2313",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Sensitive and responsive pentiptycene-based molecular fluorescence chemosensor for detection of polyamines

AU - Huang, Junrong

AU - Ye, Weijian

AU - Zha, Shuai

AU - Tao, Yezi

AU - Yang, Min

AU - Huang, Ke

AU - Liu, Jiqiang

AU - Fung, Yan Ho

AU - Li, Yang

AU - Li, Penghao

AU - Zhu, Lizhi

AU - Lee, Chi Sing

N1 - Funding Information: This work was supported by the Shenzhen Science, Technology and Innovation Committee ( JCYJ20150626111042525 and JCYJ20160330095659560 ), Shenzhen Key Medical Discipline Construction Fund (No. SZXK060 ), Chinese Postdoctoral Science Foundation ( 2019M663109 ), Hong Kong Baptist University ( RC-SGT2/18–19/SCI/005 and RC-ICRS-18-19-01A ), Peking University Shenzhen Graduate School andShenzhen Second People's Hospital .

PY - 2021/4

Y1 - 2021/4

N2 - A rapid and convenient detection method for biogenic polyamines is of great importance for early diagnosis of many diseases. In this work, a tetraphenyl ethylene (TPE) conjugated pentiptycene has been synthesized and showed to be a highly responsive fluorescent sensor toward polyamines. The detection limit of this probe is in the sub-micromolar level, and it also shows good selectivity for spermine. This small organic molecular bio-indicator can be used to detect spermine in artificial urine, demonstrating the potential application in clinical practice.

AB - A rapid and convenient detection method for biogenic polyamines is of great importance for early diagnosis of many diseases. In this work, a tetraphenyl ethylene (TPE) conjugated pentiptycene has been synthesized and showed to be a highly responsive fluorescent sensor toward polyamines. The detection limit of this probe is in the sub-micromolar level, and it also shows good selectivity for spermine. This small organic molecular bio-indicator can be used to detect spermine in artificial urine, demonstrating the potential application in clinical practice.

KW - Chemosensor

KW - Pentiptycene

KW - Responsive luminescence

KW - Spermine

KW - Tetraphenyl ethylene

UR - https://www.scopus.com/pages/publications/85098119415

U2 - 10.1016/j.jlumin.2020.117856

DO - 10.1016/j.jlumin.2020.117856

M3 - Journal article

AN - SCOPUS:85098119415

SN - 0022-2313

VL - 232

JO - Journal of Luminescence

JF - Journal of Luminescence

M1 - 117856

ER -

Sensitive and responsive pentiptycene-based molecular fluorescence chemosensor for detection of polyamines

Abstract

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