A rapid and convenient detection method for biogenic polyamines is of great importance for early diagnosis of many diseases. In this work, a tetraphenyl ethylene (TPE) conjugated pentiptycene has been synthesized and showed to be a highly responsive fluorescent sensor toward polyamines. The detection limit of this probe is in the sub-micromolar level, and it also shows good selectivity for spermine. This small organic molecular bio-indicator can be used to detect spermine in artificial urine, demonstrating the potential application in clinical practice.
Scopus Subject Areas
- Atomic and Molecular Physics, and Optics
- Condensed Matter Physics
- Responsive luminescence
- Tetraphenyl ethylene