Sensitive and responsive pentiptycene-based molecular fluorescence chemosensor for detection of polyamines

Junrong Huang, Weijian Ye, Shuai Zha, Yezi Tao, Min Yang, Ke Huang, Jiqiang Liu, Yan Ho Fung, Yang Li, Penghao Li, Lizhi Zhu, Chi Sing LEE*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

A rapid and convenient detection method for biogenic polyamines is of great importance for early diagnosis of many diseases. In this work, a tetraphenyl ethylene (TPE) conjugated pentiptycene has been synthesized and showed to be a highly responsive fluorescent sensor toward polyamines. The detection limit of this probe is in the sub-micromolar level, and it also shows good selectivity for spermine. This small organic molecular bio-indicator can be used to detect spermine in artificial urine, demonstrating the potential application in clinical practice.

Original languageEnglish
Article number117856
JournalJournal of Luminescence
Volume232
DOIs
Publication statusPublished - Apr 2021

Scopus Subject Areas

  • Biophysics
  • Biochemistry
  • Chemistry(all)
  • Atomic and Molecular Physics, and Optics
  • Condensed Matter Physics

User-Defined Keywords

  • Chemosensor
  • Pentiptycene
  • Responsive luminescence
  • Spermine
  • Tetraphenyl ethylene

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