Self-Assembly of Electron Donor-Acceptor-Based Carbazole Derivatives: Novel Fluorescent Organic Nanoprobes for Both One- and Two-Photon Cellular Imaging

Jinfeng Zhang, Wencheng Chen, Sergii Kalytchuk, King Fai Li, Rui Chen, Chihaya Adachi*, Zhan Chen, Andrey L. Rogach, Guangyu Zhu, Peter K.N. Yu, Wenjun Zhang, Kok Wai CHEAH, Xiaohong Zhang, Chun Sing Lee

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

In this study, we report fluorescent organic nanoprobes with intense blue, green, and orange-red emissions prepared by self-assembling three carbazole derivatives into nanorods/nanoparticles. The three compounds consist of two or four electron-donating carbazole groups linked to a central dicyanobenzene electron acceptor. Steric hindrance from the carbazole groups leads to noncoplanar 3D molecular structures favorable to fluorescence in the solid state, while the donor-acceptor structures endow the molecules with good two-photon excited emission properties. The fluorescent organic nanoprobes exhibit good water dispersibility, low cytotoxicity, superior resistance against photodegradation and photobleaching. Both one- and two-photon fluorescent imaging were shown in the A549 cell line. Two-photon fluorescence imaging with the fluorescent probes was demonstrated to be more effective in visualizing and distinguishing cellular details compared to conventional one-photon fluorescence imaging.

Original languageEnglish
Pages (from-to)11355-11365
Number of pages11
JournalACS applied materials & interfaces
Volume8
Issue number18
DOIs
Publication statusPublished - 11 May 2016

Scopus Subject Areas

  • Materials Science(all)

User-Defined Keywords

  • carbazole derivatives
  • electron donor-acceptor
  • fluorescent organic nanoprobes
  • self-assembly
  • two-photon cellular imaging

Fingerprint

Dive into the research topics of 'Self-Assembly of Electron Donor-Acceptor-Based Carbazole Derivatives: Novel Fluorescent Organic Nanoprobes for Both One- and Two-Photon Cellular Imaging'. Together they form a unique fingerprint.

Cite this